尼可地尔在持续性肌钙蛋白I弱阳性心绞痛患者中的作用

目的：探讨尼可地尔在持续性肌钙蛋白 I （TnI）弱阳性不稳定型心绞痛患者中的作用。方法：选择伴有持续性肌钙蛋白 I （TnI）弱阳性的不稳定性心绞痛患者111例，随机分为对照组（55例，接受常规治疗）和干预组（56例，在常规治疗基础上加用尼可地尔片（5mg，3次/d）；观察，比较两组患者治疗1周内胸痛缓解情况，3个月内因胸痛加重的再住院情况，1年内心源性死亡情况。结果：与对照组比较，干预组1周内两组症状缓解率显著上升（63.6％比91.1％，χ^2＝11.97，P＝0.0005）；3个月内胸痛加重再发住院显著减少（56.4％比19.6％，χ^2＝15.91，P＝0.0001）；但1年内两组心源性死亡率无显著差异（5.5％比8.9％，χ^2＝0.50，P＝0.4792）。结论：尼可地尔可明显改善持续性TnI弱阳性不稳定型心绞痛患者的症状，而且减少患者因心绞痛加重的再住院率，但一年内死亡率两组没有明显差别。

Effect of Nicorandil on unstable angina patients with persistent weak positive for troponin-I

Objective：To discuss effect of nicorandil on unstable angina patients With persistent Weakly positive for troponin I （TnI）.Methods：A total of 111 unstable angina patients With persistent Weakly positive for TnI Were randomly divided into control group （received routine treatment,55 cases） and intervention group （received nic-orandil 5mg,3 times/d based on routine treatment,56 cases）.The relief of chest pain in one Week,the recurrent hospitalization for chest pain aggravation in 3 months and the cardiac mortality rate in one year betWeen tWo groups Were observed in tWo groups. Results：Compared With control group,the relief of angina pectoris in one Week （63.6% vs. 91.1%,χ^2=11.97,P=0.0005）significantly increased,re-hospitalization for chest pain aggravation in three months （56.4% vs.19.6%,χ^2=15.91,P=0.0001）significantly decreased in intervention group;but cardiac mortality rate during one year betWeen tWo groups Was no significant difference （5.5% vs. 8.9%,χ^2=0.50,P=0.4792）.Conclusion：Nicorandil can significantly reduce the unstable angina and re-hospitalization for chest pain aggravation in patients With persistent Weakly positive for TnI,but there Was no significant difference in reducing mortality Within one year betWeen tWo groups.