氨氯地平并特拉唑嗪治疗中老年高血压的疗效与安全性

目的：观察氨氯地平联合特拉唑嗪治疗中老年男性原发性高血压的短期临床疗效及安全性。方法：选择我院2011年1月～2012年2月收治的患有原发性高血压的中老年男性患者64例，随机分为氨氯地平组（单用氨氯地平治疗）和联合用药组（采用氨氯地平联合特拉唑嗪治疗），每组各32例。结果：联合用药组总有效率为93.75％，明显高于氨氯地平组的65.63％（P ＝0.028）；两组治疗后收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、甘油三酯（TG）及空腹血糖（FPG）水平均明显降低（P ＜0.05～＜0.01）；与氨氯地平组比较，联合用药组降低更为显著[SBP：（138.55±7.96）mmHg 比（110.65±7.28）mmHg，DBP：（93.35±5.86）mmHg 比（80.11±5.93） mmHg，TC：（5.67±0.76）mmol/L 比（4.22±0.63）mmol/L，TG：（2.67±0.86）mmol/L 比（2.01±0.75） mmol/L，FBG：（5.69±0.86）mmol/L 比（4.31±0.58）mmol/L]，P 均＜0.05；联合用药组不良反应发生率（6.25％）明显低于氨氯地平组（18.75％），P ＜0.05。结论：氨氯地平联合特拉唑嗪治疗中老年男性原发性高血压临床效果显著，可有效降低患者收缩压和舒张压，不良反应少，值得临床推广。

Therapeutic effect and safety of amlodipine combined terazosin on middle and old aged male patients with essential hypertension

Objective：To observe the short-term therapeutic effect and safety of amlodipine combined terazosin on middle and old aged male patients with essential hypertension （EH）.Methods：A total of 64 middle and old aged male EH patients treated in our hospital from Jan 2011 to Feb 2012 were enrolled.They were randomly and equally divided into amlodipine group and combined therapy group （received amlodipine combined terazosin treatment）.Re-sults：Total effective rate of combined therapy group （93.75%）was significantly higher than that of amlodipine group （65.63%）,P =0.028;there were significant reductions in levels of systolic blood pressure （SBP）,diastolic blood pressure （DBP）,total cholesterol （TC）,triglyceride （TG）and fasting plasma glucose （FPG）in both groups after treatment （P 〈0.05~〈0.01）,compared with amlodipine group,there were more significant reductions in these indexes [SBP：（138.55±7.96）mmHg vs.（110.65±7.28）mmHg,DBP：（93.35±5.86）mmHg vs.（80.11 ±5.93）mmHg,TC：（5.67±0.76）mmol/L vs.（4.22±0.63）mmol/L,TG：（2.67±0.86）mmol/L vs.（2.01± 0.75）mmol/L,FBG： （5.69±0.86）mmol/L vs.（4.31±0.58）mmol/L]in combined therapy group,P 〈0.05 all;incidence rate of adverse reactions in combined therapy group （6.25%）was significantly lower than that of am-lodipine group （18.75%）,P 〈0.05. Conclusion：Amlodipine combined terazosin possesses more therapeutic effect in middle and old aged male patients with essential hypertension.It can effectively reduce systolic and diastolic blood pressure;the adverse reactions are fewer,so it＇s worth extending in clinic.