非那雄胺对老年单纯收缩期高血压合并良性前列腺增生患者的疗效及安全性

目的：分析应用非那雄胺对老年单纯收缩期高血压（ISH）合并良性前列腺增生（BPH）患者的疗效及安全性。方法：选择84例2011年6月至2013年5月我院的ISH合并BPH老年患者，依据给药方案不同分为：非那雄胺组（44例）；常规治疗组（40例，行常规治疗不使用非那雄胺）。疗程均为半年，比较两组国际前列腺症状评分（IPSS）、生活质量评分（QOL），前列腺特异性抗原（PSA）、急性尿潴留发生率、最大尿流率（Qmax）、膀胱残余尿量（PRV）、前列腺体积（PV）以及不良反应发生率。结果：与常规治疗组相比，非那雄胺组的 IPSS 评分[（13.2±2.4）分比（9.4±1.1）分]、PRV [（21.4±4.6）ml比（9.0±2.3）ml]、PV [（36.8±3.8）ml比（29.5±3.0）ml]、PSA [（2.45±0.74）μg/L比（1.26±0.48）μg/L]及急性尿潴留发生率（17.50％比9.09％）显著降低（P＜0.05或＜0.01），而 Qmax [（10.2±2.4）ml比（13.7±3.8）ml]及 QOL评分[（3.1±1.0）分比（4.7±1.5）分]则显著升高（P＜0.05）。两组各项不良反应发生率无统计学差异（P 均＞0.05）。结论：单纯收缩期高血压合并良性前列腺增生老年患者应用非那雄胺的疗效显著，且不良反应未显著增加。

Therapeutic effect and safety of finasteride for aged patients with isolated systolic hypertension compli-cated benign prostatic hyperplasia

Objective：To analyze the therapeutic effect and safety of finasteride on aged patients with isolated systolic hypertension （ISH）complicated benign prostatic hyperplasia （BPH）.Methods：A total of 84 aged ISH ＋ BPH patients admitted from Jun 2011 to May 2013 were selected.According to medication plan,they were divided into finasteride group （n=44）and routine treatment group （n=40,only received routine treatment because they cannot use finasteride）.Course of treatment was all six months.International prostate symptom score （IPSS）,quality of life （QOL） questionnaire score,prostate-specific antigen （PSA）,incidence rate of acute urinary retention,maximum urinary flow rate （Qmax）,postvoid residual urine （PRV）,prostate volume （PV）and incidence rate of adverse reactions were compared between two groups.Results：Compared with routine treatment group,there were significant reductions in IPSS [（13.2±2.4）scores vs.（9.4±1.1）scores],PRV [（21.4±4.6）ml vs.（9.0±2.3）ml],PV [（36.8±3.8）ml vs.（29.5±3.0）ml],PSA [（2.45±0.74）μg/L vs.（1.26±0.48）μg/L]and incidence rate of acute urinary retention （17.50% vs.9.09%）,P〈0.05 or 〈0.01,and significant increase in Qmax [（10.2±2.4） ml vs.（13.7±3.8）ml]and QOL score [（3.1±1.0）scores vs.（4.7±1.5）scores]in finasteride group （P〈0.05）. There were no significant difference in incidence rates of adverse reactions between two groups,P〉0.05 all.Conclusion：Therapeutic effect of finasteride is significant and adverse reactions don’t increase significantly in aged patients with isolated systolic hypertension complicated benign prostatic hyperplasia.