糖化血红蛋白与糖耐量正常老年人颈动脉硬化的关系

目的：探讨糖化血红蛋白（HbAlc）与糖耐量正常的老年人颈动脉硬化的关系。方法：选择100例糖耐量正常的老年患者，采用彩色多普勒超声诊断仪检测患者双侧颈动脉，依据颈动脉内膜中层厚度（CIMT）（正常、增厚、硬化）和斑块形态（无斑块、硬斑、软斑）分别进行分组，比较组间血压、血脂、糖化血红蛋白等指标。结果：（1）随着颈动脉内膜中层厚度的增加，糖化血红蛋白数值显著升高（4．98±0．55）％比（5．51±0．42）％比（5．92±0．39）％]，两两比较有统计学意义（P均〈0．01）；（2）无斑块组、硬斑组和软斑组HbAlc水平分别为（5．36±0．51）％、（5．89±0．44）％和（5．97±0．2）％，硬、软斑块组均显著高于无斑块组（P均〈0．01）。结论：糖化血红蛋白有待成为评估老年人颈动脉硬化的重要指标。

Relationship between glycosylated hemoglobin and carotid artery atherosclerosis in aged patients with normal glucose tolerance

Objective： To explore the relationship between glycosylated hemoglobin （HbAlc） and carotid artery atherosclerosis in aged patients with normal glucose tolerance. Methods： A total of 100 aged patients with normal glucose tolerance were selected. Their bilateral carotid arteries were measured by color Doppler ultrasonography. They were grouped according to carotid intima-media thickness （C-IMT, normal, thicken and atherosclerosis） and plaque form （no plaque, hard plaque and soft plaque） ; blood pressure, blood lipids and HbAlc etc. were compared among groups. Results： （1） Along with CIMT rose, there was significant increase in HbAlc level （4. 98 ± 0.55）% vs. （5.51± 0.42）% vs. （5.92± 0. 39） %1, and there was significant difference between any two groups （P〈0.01 all） ; （2） HbAlc level was （5.36 ± 0.51）%, （5.89 ± 0. 44） % and （5. 97 ± 0.2） % in no plaque group, hard plaque group and soft plaque group respectively, and there was significant difference among hard plaque group, soft plaque group and no plaque group （P〈0.01 all）. Conclusion： Glycosylated hemoglobin may become an important index assessing carotid atherosclerosis in aged people.