Localization of leukocytes and cytokines in chorionic villi of normal placentas and complete hydatidiform moles |
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Authors: | Ross S. Berkowitz M.D. Heidi M.P. Faris B.A. Joseph A. Hill M.D. Deborah J. Anderson Ph.D. |
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Affiliation: | New England Trophoblastic Disease Center, Fearing Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115. |
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Abstract: | Monoclonal antibodies were used to localize and characterize leukocytes and cytokines in chorionic villi of normal placenta and complete mole. OKT4a reacted with Hofbauer cells in first-, second-, and third-trimester placentas. HLA-DR was expressed on second- and third-trimester placental Hofbauer cells but was not detected in the first trimester. The cytokines, gamma-interferon, granulocyte-macrophage colony-stimulating factor, interleukin-1 alpha, and tumor necrosis factor alpha, were all detectable on Hofbauer cells in first-, second-, and third-trimester placentas. None of the tested cytokine antibodies reacted with cellular constituents in complete molar chorionic villi. The absence of cytokine-positive cells in molar chorionic villi may be related to the hyperplastic and unregulated growth of molar villous trophoblast. |
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