| 阿昔洛韦片体内生物利用度研究 |
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| 引用本文： | 童荣生,何林,孙世明,吴正中. 阿昔洛韦片体内生物利用度研究[J]. 西北药学杂志, 2001, 16(2): 70-71 |
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| 作者姓名： | 童荣生 何林 孙世明 吴正中 |
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| 作者单位： | 四川省人民医院临床药理研究室 |
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| 摘 要： | 研究两种阿昔洛韦片药物动力学及生物等效性。采用反相高效液相色谱法 ( C18柱 ,流动相为 0 .1%醋酸溶液 ,流速 1.4 ml/min,测定波长 2 54nm)测定 10名志愿受试者单剂量口服 60 0 mg阿昔洛韦片后 ,阿昔洛韦血药浓度变化情况。结果表明供试品和参比制剂为生物等效制剂。药时曲线下面积分别是 :5.30± 1.19(μg· h) /ml与 5.4 1± 1.34 ( μg· h) /ml,达峰时间分别为 :1.84± 0 .55h与 1.97± 0 .39h,峰浓度分别是 :1.0 9± 0 .18μg/ml与 1.0 6± 0 .2 2 μg/ml。
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| 关 键 词： | 阿昔洛韦 药代动力学 生物利用度 片剂 |
| 修稿时间： | 2000-10-13 |
Study on relativebioavailability of acyclovir tablets in healthy volunteers |
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| Tong Rongsheng,He Lin,Sun Shiming,Wu Zhengzhong. Study on relativebioavailability of acyclovir tablets in healthy volunteers[J]. Northwest Pharmaceutical Journal, 2001, 16(2): 70-71 |
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| Authors: | Tong Rongsheng He Lin Sun Shiming Wu Zhengzhong |
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| Abstract: | The pharmacokinetics and relative bioavailability of two kinds of acyclovir tablets were studied. Acyclovir concentration in the plasma was detected by RP-HPLC after taken orally 600mg of acyclovir tablets respectively by 10 volunteers according an open randomized cross-over test. The results showed that the AUC0→∞ of acyclovir of the two formulations were(5.30±1.19)μg*h/ml and (5.41±1.34)μg*h/ml；Tmax were(1.84±0.55)h and (1.97±0.39)h; Cmax were(1.09±0.18)μg/ml and (1.06±0.22)μg/ml respectively. The statistical analysis demonstrated two kinds of acycolvir tablets were bioequivalent. |
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| Keywords: | acyclovir pharmacokinetics bioavailability tablets |
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