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| 多巴胺受体激动剂的神经保护作用 | |
| 引用本文： | 杜芳,李锐,李俊枝,乐卫东.多巴胺受体激动剂的神经保护作用[J].中国新药与临床杂志,2005,24(2):151-155. |
| 作者姓名： | 杜芳 李锐 李俊枝 乐卫东 |
| 作者单位： | 1. 上海第二医科大学附属瑞金医院,生物医学研究院,上海,200025;中国人民解放军第四军医大学附属西京医院,神经内科,陕西,西安,710032 2. 西安铁路中心医院,老年科,陕西,西安,710032 3. 上海第二医科大学附属瑞金医院,生物医学研究院,上海,200025 |
| 摘 要： | 左旋多巴和多巴胺受体激动剂是目前主 要应用于治疗帕金森病的药物。但近年来在体和离 体研究显示左旋多巴可能对多巴胺神经元有神经毒 性,而多巴胺受体激动剂对黑质纹状体系统的神经 元具有保护作用。这种神经保护作用可能是通过抗 氧化、神经营养、抗凋亡和稳定线粒体膜的机制实现 的。本文回顾了近年来多巴胺受体激动剂神经保护 作用的机制研究,认为这类药物除了具有症状改善 作用外,还可能具有延缓帕金森病病程进展的作用。 |
| 关 键 词： | 帕金森病 多巴胺激动剂 神经保护药 |
| 文章编号： | 1007-7669(2005)02-0151-05 |
| 修稿时间： | 2003年12月15 |
Neuroprotective effect of dopamine receptor agonists |
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| DU Fang,LI Rui,LI Jun-zhi,LE Wei-dong.Neuroprotective effect of dopamine receptor agonists[J].Chinese Journal of New Drugs and Clinical Remedies,2005,24(2):151-155. | |
| Authors: | DU Fang LI Rui LI Jun-zhi LE Wei-dong |
| Institution: | DU Fang 1,2,LI Rui 1,2,LI Jun-zhi3,LE Wei-dong1 |
| Abstract: | Levodopa and dopamine receptor agonists are the main therapeutic drugs currently used for Parkinson's disease (PD). However recently in vitro and in vivo studies have revealed that levodopa may be neurotoxic to dopamine neuron, while dopamine receptor agonists may have neuroprotective effect against neuronal injury in the nigro-striatal system. This neuroprotective effect of dopamine receptor agonists may resulted from the mechanism through their properties concerning about the antioxidation, neurotrophic stimulation, antiapoptosis and mitochondrial membrane potential stabilization. This paper retrospectively present the evidences and mechanisms of neuroprotection provided by several dopamine receptor agonists, such as apomorphine, pramipexole and ropinirole, and suggests that these drugs may be able to slow down the progression of the disease in addition to their symptomatic relief of PD. |
| Keywords: | Parkinson disease dopamine agonists neuroprotective agents |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |