| 灭螺增效剂的合成 |
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| 引用本文： | 王苏皖,王锐,彭司勋.灭螺增效剂的合成[J].药学学报,1992,27(4):261-267. |
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| 作者姓名： | 王苏皖 王锐 彭司勋 |
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| 作者单位： | 南京药物研究所，南京药物研究所，南京药物研究所 1990届硕士研究生 徐州医学院生理教研室 邮政编码 221002，南京 210009，南京 210009 |
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| 摘 要： | 药物灭螺是血吸虫病防治的重要环节之一,为了寻找更好的灭螺增效剂,设计合成了O,O′-二烷基-O″-(2-取代-3-苯并呋喃乙腈-α-肟)磷酸酯和硫代磷酸酯(Ⅵ1～13),O,O′-二烷基-O″-(2-噻吩乙腈-α-肟)磷酸酯(Ⅹ14,15)等化合物15个。初步试验表明,化合物X15与五氯酚钠合用有较强灭螺增效作用,化合物Ⅹ14及Ⅵ1,2,3,6,8,10,12,13亦有一定的灭螺增效活性,化合物Ⅵ10,12除增效作用外本身尚有一定的杀螺活性。
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| 关 键 词： | 灭螺增效剂 O O′-二烷基-O″-(2-取代-3-苯并呋喃乙腈-α-肟)磷酸酯 O O′-二烷基-O″-(2-噻吩乙脯-α-肟)磷酸酯 |
| 收稿时间： | 1991-03-25 |
SYNTHESIS OF MOLLUSCICIDAL SYNERGISTS |
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| SW Wang,R Wang,SX Peng.SYNTHESIS OF MOLLUSCICIDAL SYNERGISTS[J].Acta Pharmaceutica Sinica,1992,27(4):261-267. |
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| Authors: | SW Wang R Wang SX Peng |
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| Institution: | Nanjing Institute of Materia Medica. |
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| Abstract: | Chemical molluscicides are useful in schistosomiasis control. A synergist can potentiate the efficacy and reduce the dosage of a molluscicide, thus decreasing the toxicity and environmental pollution. In order to search for potential molluscicidal synergists, 13 compounds of O,O-dialkyl-O-(2-substituted-3-benzofurylacetonitrile-alpha-oxi mino)phosphate or thiophosphate (VI1-13) and 2 compounds of O,O-dialkyl-O-(2-thienylacetonitrile-alpha-oximino)phosphate (X14,15) were prepared. Preliminary test demonstrated that compound X15 had strong synergic effect with sodium pentachlorophenol in combating mollusks. Compounds X14 and VI1,2,3,6,8,10,12,13, also showed some molluscicidal synergistic activity. |
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| Keywords: | O O'--dialkyl--O'--(2--substituted--3--benzo--furylacetonitrile--α--oximindno)phosphate O O'--Dialkyl--O'--(2--thienylacetonitrile--α--oximino)phosphate molluscacidal synergist |
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