| 苏合心鼻吸贴体内外相关性试验的研究 |
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| 引用本文： | 李孝栋,张凌燕,叶蕻芝,汪正来. 苏合心鼻吸贴体内外相关性试验的研究[J]. 福建中医学院学报, 2009, 19(2) |
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| 作者姓名： | 李孝栋 张凌燕 叶蕻芝 汪正来 |
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| 作者单位： | 1. 福建中医学院药学系,福建,福州,350108
2. 福建中西医结合研究院,福建,福州,350108 |
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| 基金项目： | 福建省教育厅重点项目，陈可冀中西医结合发展基金 |
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| 摘 要： | 目的 研究苏合心鼻吸贴体外释放度和体内吸收度的相关性. 方法 采用气相-质谱联用(GC-MS)技术,以冰片为测试目标,对苏合心鼻吸贴中冰片的释放度行为和鼻吸贴经家免鼻子吸入后在其体内的吸收度行为进行了研究,并对二者的相关性做了比较. 结论 6 h内鼻吸贴的释放度为21.1%,家兔体内的吸收度为41.3%,释放度和吸收度的相关关系为Y=2.5151X-6.0916,r=0.9973. 结论 苏合心鼻吸贴中冰片的释放度和吸收度具有较好的相关性.
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| 关 键 词： | 苏合心鼻吸贴 释放度 吸收度 体内外相关性 |
Studies on Correlation of Suhexin Nasal Inhalant in Vitro and in Vivo |
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| LI Xiao-dong,ZHANG Ling-yan,YE Hong-zhi,et al. Studies on Correlation of Suhexin Nasal Inhalant in Vitro and in Vivo[J]. Journal of Fujian College of Traditional Chinese Medicine, 2009, 19(2) |
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| Authors: | LI Xiao-dong ZHANG Ling-yan YE Hong-zhi et al |
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| Affiliation: | 1.Department of pharmacy;FUTCM;Fuzhou;Fujian 350108;China;2.Fujian Academy of Integrative Medicine;China |
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| Abstract: | Objective To study the correlation between release percentage in vitro and absorption percentage in vivo of Suhexin nasal inhalant.Methods The release percentage of borneol in vitro and its absorption percentage in vivo from Suhexin nasal inhalant in rabbits were studied and their correlation was compared with technology of gas chromatography and mass spectra(GC-MS).Results The release percent-age of the inhalant in 6 hours was 21.1%,and the absorption percentage in rabbits was 41.3%.The correla-tion betwee... |
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| Keywords: | GC-MS |
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