| 喉癌中环氧化酶-2和血管生成素-2的表达及其相关性 |
| |
| 引用本文： | 覃纲,陈祖尧,余玲,梁灼萍,刘文军,黎万荣. 喉癌中环氧化酶-2和血管生成素-2的表达及其相关性[J]. 肿瘤防治研究, 2008, 35(12) |
| |
| 作者姓名： | 覃纲 陈祖尧 余玲 梁灼萍 刘文军 黎万荣 |
| |
| 作者单位： | 1. 四川泸州医学院附属医院耳鼻咽喉一头颈外科,646000
2. 四川泸州医学院附属医院眼科,646000 |
| |
| 基金项目： | 四川省应用基础研究计划 |
| |
| 摘 要： | 目的 研究COX-2和Ang-2在喉癌中的表达及其相关性.方法 应用免疫组织化学SP法检测65例喉癌组织及34例癌旁阴性喉黏膜组织中COX-2和Ang-2的表达.并结合相关临床病理参数进行分析.结果 COX-2和Ang-2蛋白在喉癌组织中的阳性表达率分别为63.08%和69.23%,均高于癌旁喉黏膜组织中的表达(P<0.05).C0X-2及Ang-2的表达都与T分期和临床分期相关,且两者表达呈显著正相关性(P<0.05).Kaplan-Meier分析显示COX-2阳性表达和阴性表达组患者无瘤生存率和总生存率差异有统计学意叉,但Ang-2表迭仅影响患者的总生存率(P<0.05).结论 COX-2与Ang-2在喉癌表达异常增高,且呈正相关表达,其可能通过促进血管生成在肿瘤的形成、浸润、扩散等过程中发挥着重要作用,两者可作为判断喉癌生物学行为和预后的重要指标.
|
| 关 键 词： | 环氧化酶-2 血管生成素-2 喉肿瘤 癌 鳞状细胞 血管生成 |
Expression of COX-2 and Ang-2 and Their Correlation in Laryngeal Carcinoma Tissue |
| |
| QIN Gang,CHEN Zu-yao,YU Ling,LIANG Zhuo-ping,LIU Wen-jun,LI Wan-rong. Expression of COX-2 and Ang-2 and Their Correlation in Laryngeal Carcinoma Tissue[J]. Cancer Research on Prevention and Treatment, 2008, 35(12) |
| |
| Authors: | QIN Gang CHEN Zu-yao YU Ling LIANG Zhuo-ping LIU Wen-jun LI Wan-rong |
| |
| Affiliation: | QIN Gang1,CHEN Zu-yao1,YU Ling2,LIANG Zhuo-ping1,LIU Wen-jun1,LI Wan-rong11. Department of Otolaryngology Head , Neck Surgery,Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China,2. Department of Ophthalmology |
| |
| Abstract: | Objective To investigate the expression of Cyclooxygenase-2(COX-2) and Angiopoietin-2(Ang-2) in laryngeal carcinoma tissue and their correlation.Methods Sixty-five samples of laryngeal carcinoma and thirty-four biopsies of adjacent noncancerous tissue were immunohistochemically examined for expression of COX-2 and Ang-2, whose relationship with clinicopathological parameters was also analyzed.Results Percentages of COX-2 and Ang-2 expression in laryngeal carcinoma tissue were 63.08% and 69.23% respectively,... |
| |
| Keywords: | Cyclooxygenase-2 Angiopoietin-2 Laryngeal neoplasms Carcinoma squamous cell Angiogenesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
