| Tamm-Horsfall蛋白在肾小管间质性肾炎免疫发病机理中的作用 |
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| 引用本文： | 侯凡凡,叶任高,李仕梅. Tamm-Horsfall蛋白在肾小管间质性肾炎免疫发病机理中的作用[J]. 中山大学学报(医学科学版), 1994, 0(2) |
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| 作者姓名： | 侯凡凡 叶任高 李仕梅 |
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| 作者单位： | 中山医科大学肾脏研究所 |
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| 摘 要： | 作者从单核、淋巴因子的角度探讨了Ｔａｍｍ－Ｈｏｒｓｆａｌｌ蛋白（ＴＨＰ）与免疫系统的关系，以及ＴＨＰ通过自身免疫反应诱发肾小管间质性肾炎（ＴＩＮ）的机制。系列研究的结果提示，在生理状态下。ＴＨＰ可能参于了肾脏对某些细胞因子，诸如白细胞介素１、白细胞介素２和肿瘤坏死因子的清除与代谢。当某些病理状态致ＴＨＰ直接进入肾间质时，则可能通过激发细胞免疫反应导致ＴＩＮ。单核／巨噬细胞及其分泌的某些单核因子是介导这类ＴＩＮ组织炎症和纤维化的关键因素。这一结论不仅有助于进一步阐明ＴＨＰ的病理生理作用。同时也可能给某些ＴＩＮ的治疗以新的启示。
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| 关 键 词： | Tamm－Horsfall蛋白，细胞因子受体，白细胞介素2，肿瘤坏死因子，肾小管间质肾炎，单核细胞，巨噬细胞，前列腺素E |
THE ROLE OF TAMM-HORSFALL PROTEIN IN THE IMMUNOPATHOGENESIS OF TUBULOINTERSTITIAL NEPHRITLS |
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| Hou Fanfan, Ye Rengao, Li Shimei. THE ROLE OF TAMM-HORSFALL PROTEIN IN THE IMMUNOPATHOGENESIS OF TUBULOINTERSTITIAL NEPHRITLS[J]. Journal of Sun Yatsen University(Medical Sciences), 1994, 0(2) |
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| Authors: | Hou Fanfan Ye Rengao Li Shimei |
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| Abstract: | he relationship between Tamm-Horsfall protein (THP ) and cytokines and the immuno- logical mechanism was studied , by which THP triggers tubulointerstitial nephritis (TIN ). The results showed that THP might play physiologically an important role in the regulation of intrarenal bioactivity of many potent cytokines , including IL-1 , IL-2 and TNF. In some disease states , however , THP could deposit in the extra-tubular interstitium through leak- age of urine from rupture of obstructed or damaged tubules , and might be able to activate cell-mediated immunity to induce TIN. Monocytes/macrophages and monokines produced by these cells played a key role in the tissue injury in this type of TIN and probably contributed to tubulointerstitial fibrosis. Besides their significance in the understanding of the patho- physiologic effects of THP , the results may also provide a new hint for the treatment of some types of TIN. |
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| Keywords: | Tamm-Horsfall protein cytokine receptor interleukin 1 tumor necrosis factor tubulointerstitial nephritis monocyte macrophage prostaglandin |
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