| nm23-H1蛋白表达在非小细胞肺癌淋巴结转移的意义 |
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| 作者单位： | 广东佛山顺德陈村医院，广东省韶关市第一人民医院 |
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| 摘 要： | 目的:探讨nm23-H1蛋白在非小细胞肺癌(NSCLC)中的表达及与淋巴结转移的关系。方法:应用免疫组织化学法检测60例非小细胞肺癌组织中nm23-H1基因蛋白的表达。结果:NSCLC无淋巴结转移组nm23-H1蛋白阳性表达率为82.76%(24/29),高于NSCLC伴有淋巴结转移组45.16%(14/31),两者差异有统计学意义(P<0.01)。结论:NSCLC中nm23-H1蛋白低表达易发生淋巴结转移,检测nm23-H1蛋白可在一定程度上评估NSCLC的预后。
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| 关 键 词： | 非小细胞肺癌 nm23-H1 淋巴结转移 免疫组化 |
Expression of nm23-H1 in the Lymph Node Metastasis of Non-small Cell Lung Cancer |
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| JIANG Zhi-jian,WANG Xiao-ping. Expression of nm23-H1 in the Lymph Node Metastasis of Non-small Cell Lung Cancer[J]. Sichuan Journal of Cancer Control, 2008, 0(4) |
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| Authors: | JIANG Zhi-jian WANG Xiao-ping |
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| Abstract: | Objective:To explore the relationship between the expression of nm23-H1 and the lymph node metastasis of non-small cell lung cancer.Methods:The expressions of nm23-H1 in 60 cases with non-small cell lung cancer were detected by immunohistochemical staining.Results:In the groups with and without lymph node metastasis,the positive rates of nm23-H1 were 45.16%(14/31)and 82.76%(24/29)respectively with significant difference(P<0.01).Conclusion:The low expression of nm23-H1 is related to the lymph node metastasis of NSCLC. |
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| Keywords: | NSCLC nm23-H1 Lymph Node Metastasis Immunohistochemistry |
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