米氮平与氟西汀治疗抑郁症对照研究

目的：比较米氮平与氟西汀治疗抑郁症的临床疗效和安全性。方法：将60例抑郁症患者随机分为米氮平组和氟西汀组，分别给予米氮平和氟西汀治疗，疗程6周。采用汉密尔顿抑郁量表（HAMD）及治疗中出现的症状量表（TESS）评定疗效和不良反应。结果：米氮平组和氟西汀组显效率分别为80．0％和76．7％，两组疗效相仿。但治疗1周后，米氮平组的有效率高于氟西汀组。结论：米氮平是一种起效较快，安全、有效的抗抑郁药。

Comparative study between mirtazapine and fluoxetine in the treatment of depression

Objective:To compare the clinical efficacy and safety between mirtazapine and fluoxetine in the treatment of depression. Method:Sixty patients with depression were randomly divided into mirtazapine group and fluoxetine group for 6 weeks.Hamilton rating scale for depression(HAMD) and treatment emergent symptoms scale(TESS) were used to evaluate the efficacy and adverse effects. Results:There was a similar efficacy between the two groups,with response rate 80.0% for mirtazapine group and 76.7% for fluoxetine group.mirtazapine group showed a higher response rate compared with fluoxetine group after one week treatment. Conclusion:Mirtazapine is a safe and effective antidepressant,with rapid efficacy.