| THE ANTITUMOR ACTIVITIES OF GNIDIMACRIN ISOLATED FROM STELLERA CHAMAEJASMEL． |
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| 引用本文： | 冯威健.THE ANTITUMOR ACTIVITIES OF GNIDIMACRIN ISOLATED FROM STELLERA CHAMAEJASMEL．[J].中国癌症研究,1996,8(2):101-104. |
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| 作者姓名： | 冯威健 |
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| 作者单位： | Fourth Hospital of Hebei，Uedical University.，Shijiazhuang. 050011 Department of Chemotherapy，National Cancer Center. Tokyo 104. Japan |
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| 摘 要： | ＴＨＥＡＮＴＩＴＵＭＯＲＡＣＴＩＶＩＴＩＥＳＯＦＧＮＩＤＩＭＡＣＲＩＮＩＳＯＬＡＴＥＤＦＲＯＭＳＴＥＬＬＥＲＡＣＨＡＭＡＥＪＡＳＭＥＬ．ＦｅｎｇＷｅｉｊｉａｎ；冯威健ＩｋｅｋａｗａＴｅｔｓｕｒｏ；ＹｏｓｈｉｄａＭｉｔｓｕｚｉ（ＦｏｕｒｔｈＨｏｓｐｉｔ...
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| 修稿时间： | 14 February 1996 |
The antitumor activities of gnidimacrin isolated from stellera chamaejasme L. |
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| Feng Weijian,Ikekawa Tetsuro,Yoshida Mitsuzi.The antitumor activities of gnidimacrin isolated from stellera chamaejasme L.[J].Chinese Journal of Cancer Research,1996,8(2):101-104. |
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| Authors: | Feng Weijian Ikekawa Tetsuro Yoshida Mitsuzi |
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| Institution: | (1) Fourth Hospital of Hebei Medical University, 050011 Shijiazhuang;(2) Department of Chemotherapy, National Cancer Center, 104 Tokyo, Japan |
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| Abstract: | Gnidimacrin, a diterpene compound, isolated from the methanol extract ofStellera chamaejasme L., showed significant antitumor activities against mouse leukemia P-388 and L-1210in vivo, such as Lewis lung carcinoma, B-16 melanoma and Colon cancer 26. It showed ILSs of 40%, 49% and 41% at the dosages of 0.01–0.02
mg/kg ip, respectively. Gnidimacrin strongly inhibited cell proliferation of human cancer cell lines such as leukemia K562,
stomach cancers Kato-III, MKN-28, MKN-45, and mouse leukemia L-1210 by the MTT assay and colony forming assayin vitro. The IC50 of gnidimacrin was 0.007–0.00012 μmg/ml. It is concluded that gnidimacrin is the principal antitumor element inStellera chemaejasme L. with strong antitumor activities. |
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| Keywords: | Gnidimacrin antitumor drug Plant Stellera chamaejasme L |
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