2型糖尿病肾病危险因素临床分析

目的:探讨2型糖尿病肾病的临床特点及易患因素。方法:将本院收治的256例2型糖尿病患者,根据尿白蛋白排泄率和肾功能将糖尿病患者分为糖尿病无肾病组、早期肾病组、临床肾病组、终末期肾病组对照分析。结果:糖尿病4组间在年龄、病程,合并高血压、高血脂、高血尿酸、冠心病、胆结石病史、糖尿病眼病、糖尿病周围神经病变、糖尿病足,收缩压、舒张压、脉压及血糖水平差异有显著性(P<0.05);糖尿病病程、收缩压、脂代谢紊乱对糖尿病肾病的发病率差异有显著影响(P<0.05)。结论:血压、血糖、血脂控制不良导致糖尿病肾病的进展,糖尿病之间慢性血管并发症密切相关。定期检测白蛋白排泄率与血脂,严格控制血糖和血压,纠正脂代谢紊乱,有助于防治糖尿病肾病。

Clinical features and risk factors of type 2 diabetic nephropathy

Objective:To investigate the clinical features of type 2 diabetic nephropathy and analyze the risk factors of affecting incidence in order to achieve better prevention and treatment.Methods:A retrospective analysis of clinical features of diabetic nephropathy was conducted based on 256 cases in our department from 2001 to 2006.They were 87 diabetes mellitus without nephropathy,65 early diabetic nephmpathy,66 diabetic nephmpathy with overt proteinuria,38 end-stage diabetic nephmpathy.Serum levels of lipid,glucose,urea nitrogen,creadnine,uric acid,and blood pressure,albuminuria were monitored in the four groups,and their levels were compared.Results:Age,course of disease,hypertension,hyperlipidemia,hyperuricemia,coronary heart disease,biliary calculus,diabetic refinopathy,diabetic peripheral neumpathydiabetic foot,systolic and diastolic blood pressure were significantly different among four diabetic groups(P<0.05).Course of diabetes,systolic blood pressure and hyperlipidemia had significant positive effect on the incidence of diabetic nephmpathy(P<0.05).Conclusion:Dissatisfaction control of blood pressure,blood sugar and lipid result in the progression of diabetic nephmpathy.Diabetic nephmpathy is closely associated with other vascular complications.Inspecting urine albunlium excretion rate periodically,controlling blood pressure and blood sugar strictly and correctting dyslipidemia are an efective way of better prevention and treatment of diabetic nephmpathy.