The mechanism of protective effect of crocin against liver mitochondrial toxicity caused by arsenic III |
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| Authors: | Bahareh Sadat Yousefsani |
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| Institution: | Department of Pharmacodynamy and Toxicology, School of Pharmacy, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | In this study, we want to understand whether crocin could prevent mitochondrial damage caused by As III. For this purpose, we determined different mitochondrial toxicity endpoints caused by As III. We evaluated mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane potential (MMP) collapse, mitochondrial outer membrane integrity and cytochrome c release. Our results showed that pretreatment with crocin at a concentration of 25?µg/ml significantly (p?
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| Keywords: | Arsenic (As III) crocin hepatoprotection oxidative stress mitochondrial targeting antioxidant |
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