唾液腺肿瘤中survivin mRNA水平与临床病理的关系

目的：探讨唾液腺肿瘤中survivin mRNA的表达及其与唾液腺肿瘤发生、发展以及临床病理的关系。方法：制备组织芯片，应用原位杂交技术检测良、恶性唾液腺肿瘤组织以及周边腺组织中的survivin mRNA表达。采用SPSS10．0统计软件包进行x^2检验和秩和检验。结果：Survivin mRNA的表达在唾液腺良、恶性肿瘤中有显著差别（P〈0．05）；在癌旁腺体与恶性肿瘤中的表达无显著差异（P〉0．05）。在恶性肿瘤中，高分化组与中、低分化组、淋巴结转移组与未转移组、复发瘤与原发瘤间均存在显著差异fP〈O．05）；在不同性别、年龄以及不同大小肿瘤间均无显著差异（P〉0．05）。结论：Survivin mRNA的表达与唾液腺恶性肿瘤的临床病理有关，可作为唾液腺恶性肿瘤早期诊断及预后判断的可靠指标。

Expression and clinic pathological significance of survivin mRNA and protein in salivary gland tumors

PURPOSE:The study is aimed to determine the expression of survivin mRNA in salivary gland tumors and its significance in the development and progress of salivary gland tumors.METHODS:The expression of survivin mRNA both in benign and malignant salivary gland tumor tissues and in peripheral tissues was identified by in situ hybridizations assay with the prepared tissue chips.The data were analyzed by Chi-square test and rank sum test using SPSS10.0 software package.RESULTS:The difference in the expression of survivin mRNA was significant between benign and malignant salivary gland tumors(P<0.05).But not significant between the gland tissues around the tumors and malignant tumors(P>0.05).The difference in the expression of survivin mRNA in malignant salivary gland tumor was significant in the pathological grade,lymph node status and relapse of the tumor(P<0.05),But not significant in gender,age of the patients and size of the tumors(P>0.05).CONCLUSIONS:The expression of survivin mRNA is associated with clinic pathological characteristics of the malignant salivary gland tumors.Survivin mRNA may play a crucial role in earlier diagnosis and prognosis of the malignant salivary gland tumors.