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| 福氏2a志贺氏菌肠毒素基因分型 | |
| 引用本文： | 白石山,李秀霞,夏桂枝,苑宏,郑文艳,王红. 福氏2a志贺氏菌肠毒素基因分型[J]. 中华流行病学杂志, 2000, 21(4): 280-282 |
| 作者姓名： | 白石山 李秀霞 夏桂枝 苑宏 郑文艳 王红 |
| 作者单位： | 1. 010051,呼和浩特,解放军第二五三医院传染科 2. 内蒙古医学院病理教研室 3. 南京军区福州总医院儿科 4. 北京军区卫生部 5. 第一军医大学流行病学教研室 |
| 摘 要： | 目的：对福氏２ａ志贺氏菌（Ｓｈｉｇｅｌｌａ ｆｌｅｘｎｅｒｉ２ａ，Ｆ２ａ）的志贺氏肠毒素１（Ｓｈｉｇｅｌｌａ ｅｎｔｅｒｏｔｏｘｉｎ１，ＳＥＴ１）和志架氏肠毒素２（Ｓｈｉｇｅｌｌａ ｅｎｔｅｒｏｔｏｘｉｎ２，ＳＥＴ２）进行基因分型，提高菌痢暴发流行时同源性分析的水平。方法：对一起暴发Ｆ２ａ菌痢在现场流行病学调查的基础上，用聚合酶链反应（ＰＣＲ）方法，检测４３株Ｆ２ａ菌的志贺氏肠毒素１基因（ｓｅｔ１ |
| 关 键 词： | 福氏2a志贺氏菌肠毒素 PCR 基因分型 细菌性痢疾 |
| 收稿时间： | 1999-11-26 |
| 修稿时间： | 1999-11-26 |
Gena types of Shigella enterotoxins of S.flexneri 2a |
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| BAI Shishan,LI Xiuxi,XIA Guizhi,Yuan Hong,Zheng Wenyan and Wang Hong. Gena types of Shigella enterotoxins of S.flexneri 2a[J]. Chinese Journal of Epidemiology, 2000, 21(4): 280-282 | |
| Authors: | BAI Shishan LI Xiuxi XIA Guizhi Yuan Hong Zheng Wenyan Wang Hong |
| Affiliation: | Department of Infectious diseases, The 253th Hospital of PLA, Hohhot, 010051, China. |
| Abstract: | Objective To identify homogenous clones of S.flexneri 2a, using gene distribution polymorphism of Shigella enterotoxin 1(set 1) and Shigella enterotoxin 2(set 2) in a Shigellosis outbreak caused by S.flexneri 2a. Methods In addition to field epidemiological investigation,43 strains of S.flexneri 2a were determined by polymerase chain reaction(PCR). Results The 43 strains (1 from food, 1 from a carrier, 41 from patients) were divided into 3 clones(set1 /set2 for 39 strains, set1-/set2 for 1,set1 /set2- for 3 strains). Conclusion This outbreak was caused by S.flexneri 2a. The route of transmission was contaminatedfood borne. Some sporadic cases were noticed during the outbreak. The method used in this study was satisfactory to the identification of S.flexneri 2a. |
| Keywords: | Shigella flexneri Enterotoxins Gene Polymerase chain reaction (PCR) |
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