| 扶正抑瘤颗粒对H22瘤细胞bax、bcl-2及 caspase-3蛋白表达的影响 |
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| 引用本文： | 陈弘,程卫东,赵健雄,王学习. 扶正抑瘤颗粒对H22瘤细胞bax、bcl-2及 caspase-3蛋白表达的影响[J]. 中国中医药信息杂志, 2005, 12(3): 34-35 |
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| 作者姓名： | 陈弘 程卫东 赵健雄 王学习 |
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| 作者单位： | 兰州医学院中西医结合研究所,甘肃,兰州,730000 |
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| 基金项目： | 教育部科学技术研究项目 |
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| 摘 要： | 目的观察扶正抑瘤颗粒对H 22瘤细胞bax、bcl-2及caspase-3蛋白表达的影响.方法采用免疫组织化学方法检测瘤组织切片中bax、bcl-2及caspase-3的蛋白表达.结果扶正抑瘤颗粒各治疗组bax及caspase-3的IOD值均高于模型组,与模型组比较有显著性差异(P＜0.05);扶正抑瘤颗粒各治疗组bcl-2的IOD值均低于模型组,与模型组比较有显著性差异(P＜0.05).结论通过促进bax及caspase-3的蛋白表达、抑制bcl-2基因的蛋白表达来诱导H22瘤细胞凋亡,进而发挥抑瘤效应.
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| 关 键 词： | 扶正抑瘤颗粒 蛋白表达 |
| 文章编号： | 1005-5304(2005)03-0034-02 |
| 修稿时间： | 2004-07-26 |
Effect of Fuzheng Yiliu Keli on the Protein Expression of bax, bcl-2 and caspase-3 in H22 Tumor Cells |
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| CHENG Hong,CHENG Wei-dong,ZHAO Jian-xiong,et al. Effect of Fuzheng Yiliu Keli on the Protein Expression of bax, bcl-2 and caspase-3 in H22 Tumor Cells[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2005, 12(3): 34-35 |
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| Authors: | CHENG Hong CHENG Wei-dong ZHAO Jian-xiong et al |
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| Abstract: | Objective To observe the protein expression of bax, bcl-2 and caspase-3 in H22 tumor cells by treatment of Fuzheng Yiliu Keli. Methods The protein expression of bax, bcl-2 and caspase-3 were detected with immunohistochemical ABC method. Results IOD of bax and caspase-3 in treating groups was high, which was significant compared with control group (P<0.05). IOD of bcl-2 was significantly lower than that in control group (P<0.05). Conclusion FYK could execute anti-tumor effect in inducing apoptosis of H22 tumor cells apoptosis by promoting protein expression of bax and caspase-3, decreasing protein expression of bcl-2 gene. |
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| Keywords: | H22 bax bcl-2 caspase-3 |
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