| 软脉胶囊对脑缺血再灌注大鼠的影响 |
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| 引用本文： | 李伟,田淑霄.软脉胶囊对脑缺血再灌注大鼠的影响[J].中成药,2001,23(5):359-361. |
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| 作者姓名： | 李伟 田淑霄 |
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| 作者单位： | 河北医科大学中医学院,河北,石家庄,050091 |
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| 基金项目： | 河北省医药局科技专项基金资助,No.9820313 |
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| 摘 要： | 目的：观察软脉胶囊对脑缺血再灌注大鼠的影响。方法：用结扎大鼠两侧颈总动脉和迷走神经的方法复制脑缺血再灌注模型。观察血液中的NO、6－keto-PGF1α、TXB2含量变化。结果：软脉胶囊0．81g/kg,2.43g/kg能升高6－keto-PGF1吸α,NO含量，有降低TXB2趋势。结论：软脉胶囊对脑缺血再灌注大鼠有保护作用，其作用可能通过抑血小板聚集和升高NO来实现的。
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| 关 键 词： | 软脉胶囊 脑缺血 再灌注损伤 磷酯酶 血小板聚集 大鼠 中医药治疗 |
| 文章编号： | 1001-1528(2001)05-0359-02 |
| 修稿时间： | 2000年9月30日 |
Effect of Ruanmai Capsule on Cerebral Ischemia-reperfusion Injury in Rats |
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| LI Wei,TIAN Shu-xiao.Effect of Ruanmai Capsule on Cerebral Ischemia-reperfusion Injury in Rats[J].Chinese Traditional Patent Medicine,2001,23(5):359-361. |
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| Authors: | LI Wei TIAN Shu-xiao |
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| Abstract: | Objective:To investigate the protective effects of Ruanmai Capsules on cerebral ischemia-reperfuse injury in rats.Methods:A cerebral ischemia-reperfuse model in rats was established by ligaturing bilateral arterial carotis communis and vagus nerve. NO, 6-keto-PGF 1a and TXB 2 in serum were examined. Results: Ruanmai Capsule (0.81g/kg and 2.43g/kg,po) increased the levels of NO, 6-keto-PGF 1a. It also had the tendency to decrease TXB 2 in serum. Conclusions: Ruanmai capsules can alleviate brain injury caused by cerebral ischemia reperfusion. The effect is achieved perhaps by inhibiting platelet aggregation and increasing NO. |
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| Keywords: | Ruanmai Capsule cerebral ischemia-reperfusion |
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