血浆内皮素-1水平变化在急性脑梗死诱发全身炎症反应综合征中的意义

目的:以目前外科领域及危重病领域公认的全身炎症反应综合征(SIRS)统一诊断标准,探讨血浆内皮素-1(ET-1)在急性脑梗死(ACl)诱发SIRS发生中的作用。方法:应用放射免疫法分别测定52例ACI致SIRS患者(SIRS组),50例急性单纯性脑梗死(SACl)及46例正常对照组血浆ET-1含量。结果:1血浆ET-1含量在SIRS组、SACI组与正常对照组比较,差异均具有极显著(均P<0.01)。SIRS组血浆ET-1水平又明显高于SACI组(P<0.01)。其血浆ET-1含量SIRS组>SACI组>正常对照组。2血浆ET-1含量随符合SIRS诊断标准数目的增多而升高。结论:急性脑梗死进展为SIRS后,血浆内皮素-1明显升高,血浆内皮素-1可作为判断急性脑梗死病情进展为SIRS的一项指标。

The significance of serum ET-1 content changing in the acute cerebral infarction leading to Systemic Inflammatory Response Syndrome

objective:According to SIRS diagnosed criterion of unite in surgery and critic diease field at present,the serum ET-1 of the patients were measured to explore the mecllanism of the acute cerebral infarction(ACl)leading to Systemic Inflammatory Response Syndrome(SIRS).Methods:Radioimmunoassay method was used to measure serum ET-1 content levels in 52 cases acute cerebral infartion accompanied with SIRS(SIRS group),50 cases acute simple cerebral infarction(SACI group)and 46 cases were normal control group.Results:1.The serum ET-1 content levels in patients with SIRS,SACI group were significantly different than those in patients of the normal control group(P<0.01).The serum ET-1 content levels in patients was SIRS group > SACI group> normal control group.2.The seruln ET-1 content levels in patients with SIRS was significantly different than those in the patients of SACI group(P<0.01).The serum ET-1 content levels in patients tends to higher accommpnied with SIRS diagnosed criterion numbers increasing.Conclusion:The serum ET-1 content levels in patients were higher significantly when acute cerebral infarction progress to SIRS,The serum ET-1 content changing can become the disease criteria of from AC! progressed to SIRS.