痛风的药物治疗与药学监护

高尿酸血症和痛风是多种心脑血管和代谢疾病的危险因素,是高血压、肾动脉硬化结石、尿酸性肾病、糖尿病的发病和恶化因素。抗痛风药为一组通过抑制尿酸合成和促进尿酸排泄或分解而降低血、尿尿酸水平,或抑制粒细胞浸润而控制关节炎症,对抗痛风发作的药物,其合理应用和药学监护十分重要。通过查阅近年来国内、外相关文献和诊疗指南,对痛风的药物治疗与药学监护进行综述。药师应确立痛风的治疗靶标、按痛风的分期选择用药、针对痛风合并症积极治疗,并从规避诱发尿酸水平升高的药品、急性发作期禁忌的药品、水化和碱化治疗等若干监护点进行干预,体现现代药师在药物治疗中的价值。

Drug Therapy and Pharmaceutical Care of Gout

Gout and hyperuricemia is a risk factor for various cardiovascular , cerebrovascular and metabolic diseases and can cause the onset and deterioration of hypertension , renal arteriosclerosis stones , uric acid nephropathy and diabetes . Gout Suppressant as a group of medicines can reduce the level of uric acid by inhibiting the synthesis of uric acid and promoting the excretion or decomposition of uric acid , or to control joint inflammation and gout attacks by inhibiting granulocyte invasion . The reasonable medication and pharmaceutical care are of great importance . In this paper a review was made on the drug therapy and pharmaceutical care of gout based on data research of related literature at home and abroad in recent years,as well as the guidelines for diagnosis and treatment. Pharmacist should establish the target for gout treatment , select drugs according to the staging of gout and treat actively the patient with gout complications . Intervention was given according to the monitoring points such as avoiding use of the drugs which may elevate uric acid level and the forbidden drugs during acute exacerbation , and hydration and alkalization treatments , thus the role of pharmacist in medical treatment is presented .