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Chloral hydrate anesthesia blocks the excitatory response of dorsal raphe neurons to phasic auditory and visual stimuli in cats
Authors:Michael E Trulson  Violet M Trulson
Abstract:Serotonergic neurons within the dorsal raphe nucleus were driven, with similar temporal characteristics, by phasic auditory and visual stimuli in freely moving cats. Chloral hydrate (300–350 mg/kg, i.p) produced little change in the spontaneous activity of raphe neurons (−18.7%), but completely blocked the responsiveness of these units to sensory stimulation. Based on these and other data, we hypothesized that the anesthetic inactivates a general excitatory input to the dorsal raphe nucleus.
Keywords:chloral hydrate anesthesia  excitatory response  dorsal raphe neurons  phasic auditory stimuli  visual stimuli  cat
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