信号转导抑制因子-3与磷酸化信号转导转录活化因子

Expression of SOCS-3 and p-STAT3 in laryngeal squamous cell carcinoma and the correlation with clinicopathological parameters

Objective To investigate the expression of suppressor of cytokine signaling-3(SOCS-3) in laryngeal squamous cell carcinoma(LSCC),and to study the correlation between the expression of SOCS-3 and signal transducer and activator of trans p-STAT3,and that between the expression of SOCS-3 with clinicopathological factors of LSCC.Methods Immunohistochemical staining(S-P method) was used for detecting the expression of SOCS-3,p-STAT3 in 40 specimens of surgically resected LSCC and 11 of paracancerous normal laryngeal tissue.Results ① The expression of SOCS-3 in LSCC was significantly lower than that in normal laryngeal tissue(P=0.000).The expression of p-STAT3 in normal laryngeal tissues was significantly lower than that in LSCC(P=0.000).② Significant negative correlation was observed between the expression of SOCS-3 and that of p-STAT3(r=-0.459,P=0.003).③ The expression of SOCS-3 was significantly related with the pathologic grading and lymphatic metastasis,but not with the age,gender,and clinical stage of the patients.Conclusion The SOCS-3 protein is omni-expressed in all normal laryngeal tissues,but less expressed in LSCC.The expression of SOCS-3 is negatively correlated to that of p-STAT3,which suggests that SOCS-3 plays an important role in inhibiting cell proliferation and promoting cell apoptosis in LSCC.The expression of SOCS-3 protein is not related to patients’ age,gender,T-stage and tumor position,but related to cell differentiation level and lymphatic metastasis.