Correlation between nasal eosinophils and nasal airflows in children with asthma and/or rhinitis monosensitised to house dust mites |
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Affiliation: | 1. Department of Microbiology, College of Medicine, Inje University, Busan, Republic of Korea;2. Department of Preventive Medicine, College of Medicine Kosin University, Busan, Republic of Korea;3. Department of Physiology, Kangwon National University School of Medicine, Chuncheon, Republic of Korea;4. Department of Biomedical Engineering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, Republic of Korea;5. Marine Biodiversity Institute of Korea, Sejong, Republic of Korea;6. Department of Internal Medicine, Pusan Paik Hospital, College of Medicine Inje University, Busan, Republic of Korea;7. Department of Pathology, Inje University College of Medicine, Busan, Republic of Korea;8. Department of Biochemistry, Dongeui University College of Korean Medicine, Busan, Republic of Korea |
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Abstract: | BackgroundAllergic rhinitis and asthma due to mite sensitisation are diseases which are frequently associated and characterised by persistent inflammation. In the present study, we aimed to investigate the relationship between nasal airflows and nasal eosinophils in patients with asthma and/or rhinitis due to house dust mite sensitisation.MethodsTwenty-four children with both rhinitis and asthma (R + A), 13 children with rhinitis and no asthma (R) and 10 non-allergic healthy children were evaluated prospectively. The patients belonging to the first two groups had moderate–severe grade of nasal obstruction. Total nasal symptom scores, peak nasal inspiratory flows (PNIFs) obtained by anterior rhinomanometry, skin prick tests, nasal eosinophils and FEV1 values were all assessed.ResultsPercentages of nasal eosinophils and PNIFs in patients with R + A and R (r = −0.415, p = 0.04) were found to be statistically significant and to have an inverse correlation. Skin prick tests were also significantly correlated with nasal eosinophils and PNIFs (r = 0.372, p = 0.01 and r = −0.306, p = 0.04, respectively). Both PNIFs and nasal eosinophils of patients with R + A were significantly correlated with FEV1 values (r = −0.641, p = 0.001 and r = 0.548, p = 0.007, respectively).ConclusionIn this study, a close relationship was demonstrated between eosinophil infiltration and nasal airflows in children having asthma and/or rhinitis monosensitised to mites. Additionally, the significant association found between FEV1 values and nasal eosinophils or PNIFs supported the close link of upper and lower airways. |
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