Assessment of cardiac involvement in sarcoidosis by echocardiography |
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Authors: | Marta Focardi Andrea Picchi Nikolas Nikiforakis Elena Bargagli Antonella Fossi Claudia Maggiorelli Sergio Mondillo Paola Rottoli |
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Institution: | (1) Cardiology U.O., Grosseto Hospital, Grosseto, Italy;(2) Respiratory Diseases Section, Department of Clinical Medicine and Immunology, Siena University, Siena, Italy;(3) University Cardiology, Department of Physiology, Siena University, Siena, Italy |
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Abstract: | The main objective of this study is to determine the prevalence of left ventricular systolic and diastolic dysfunction in
patients with chronic sarcoidosis without clinical evidence of heart disease. The study includes 69 chronic sarcoidosis patients,
30 diagnosed by organ biopsy and 39 by clinical history, chest X-ray, high resolution computerized tomography (HRCT) and bronchoalveolar
lavage (BAL), without suspected cardiac involvement. The control group consisted of 26 subjects selected from a population
of hospital workers. The examination includes 12-lead ECG and echocardiographic examination. The results show that there were
no differences in atrial size, left ventricular diameters, wall thickness, left ventricular ejection fraction or endocardial
fractional shortening between the sarcoid group and controls. Signs of diastolic dysfunction were found in 33 (55%) patients,
however, this group was significantly older than the others and had marginally higher blood pressure. Sarcoid patients had
lower midwall fractional shortening (mFS) than controls; patients with diastolic dysfunction also had lower mFS but the difference
was not significant. In conclusion, the results demonstrated an absence of left ventricular systolic dysfunction, evaluated
by traditional echocardiographic methods, in our chronic sarcoidosis patients and an apparent absence of any relation between
left ventricular diastolic dysfunction and sarcoidosis. Lower mFS was found among patients, particularly those with a long
history of sarcoidosis. Further analysis is required to evaluate the significance of this index as a potential marker of heart
involvement in chronic sarcoidosis. |
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Keywords: | Sarcoidosis Cardiac involvement Echocardiography |
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