| PLGA-TCP-BMP-2人工骨结合带血供自体骨修复骨缺损 |
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| 引用本文： | 周密,徐建强,李长庚,张树明,王长江,王克利,朱方正.PLGA-TCP-BMP-2人工骨结合带血供自体骨修复骨缺损[J].中国矫形外科杂志,2011,19(10):846-848. |
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| 作者姓名： | 周密 徐建强 李长庚 张树明 王长江 王克利 朱方正 |
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| 作者单位： | 第二炮兵总医院骨科,北京,100088 |
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| 基金项目： | 全军十五医药卫生科研基金课题(编号:06G018) |
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| 摘 要： | 目的]研究PLGA-TCP-BMP-2人工骨结合自体带血供自体尺骨移植修复大段骨缺损的效果.方法]手术造成30 mm绵羊桡骨骨缺损,A组置入PLGA-TCP-BMP-2人工骨及带血运的长段尺骨,B组仅置入PLGA-TCPBMP-2人工骨,C组不置人任何材料.3组均以钢板固定骨缺损区.术后24周拍摄X线片并处死动物,进行组织学观察评价.结果]X线检查示A组桡骨缺损处完全成骨修复,皮质骨与髓腔的轮廓清晰;B组亦能完全修复,但新生骨密度及髓腔轮廓清晰度均不如A组;C组无有效骨痂形成.组织学检查示A、B组骨痂外层形成为板层骨,C组缺损区可见大量纤维组织填充.结论]PLGA-TCP-BMP-2人工骨结合自体带血供长段尺骨移植能够很好的修复绵羊桡骨30 mm的骨缺损.
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| 关 键 词： | 自体骨 BMP-2 PLGA 磷酸三钙 骨缺损 |
An experiment research of the composite of BMP-2 and PLGA/tricalcium phosphate with vascularized ulna in repairing the large segmental defect of sheep radius |
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| ZHOU Mi,XU Jian-qiang,LI Chang-geng,et al..An experiment research of the composite of BMP-2 and PLGA/tricalcium phosphate with vascularized ulna in repairing the large segmental defect of sheep radius[J].The Orthopedic Journal of China,2011,19(10):846-848. |
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| Authors: | ZHOU Mi XU Jian-qiang LI Chang-geng |
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| Institution: | ZHOU Mi,XU Jian-qiang,LI Chang-geng,et al.Department of Orthopaedics,General Hospital of the 2nd Artillery Force,Beijing 100088,China |
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| Abstract: | Objective]To study the effects of the composite of PLGA-TCP-BMP-2 artificial bone with vascularized ulna in repairing the large segmental defect of sheep radius.Method]A 30 mm defect was made in middle segment of sheep radius.In group A,the composite of BMP-2 and PLGA/tricalcium phosphate with vascularized ulna was implanted into the radial defect.PLGA-TCP-BMP-2 artificial bone was implanted into the defect in group B.No material was implanted in group C.Plates were used to fix the bone in both groups.X r... |
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| Keywords: | autologous bone BMP-2 PLGA tricalcium phosphate bone defect |
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