无锡市2473例药品不良反应报告回顾性分析

目的:了解无锡市二级以上医疗机构药品不良反应(ADR)发生的特点,促进临床合理用药。方法:对无锡市ADR临床监测中心2005年1月~2006年12月收集到的无锡市属11家二级以上医疗机构上报的2473例ADR报表进行统计、分析。结果:发生ADR的人群以>60a的老年患者和≤10a的儿童居多;药物以抗感染药所致的ADR居多(占60.9%),其次为中药制剂(占13.7%);静脉给药是引起严重ADR的主要给药途径,上报的ADR大部分为已知的、轻度的ADR,严重的或罕见的ADR74例(占3.0%)。结论:临床应重视ADR的监测,ADR报表质量有待进一步提高。

Retrospective Analysis of 2 473 ADR Case Reports in the City of Wuxi

OBJECTIVE:To investigate the characteristics of adverse drug reactions(ADR)of the hospitals(Level 2 and above) of Wuxi in order to promote rational use of drugs in the clinic.METHODS:2 473 cases of ADR collected from Jan.2005 to Dec.2006 in 11 hospitals(Level 2 and above)of Wuxi were retrospectively studied.RESULTS:Most patients who had ADR were old patients over 60 years and teenagers(≤10years).Most ADR were caused by anti-infection drugs(60.9%),followed by the preparations of Chinese materia medica(13.7%).The intravenous medication was the main route of medication resulting in serious adverse reactions;Most of the ADR cases were known and mild, 74 cases were severe and scarce(3.0%).CONCLU-SION:More attention should be paid to monitoring clinical ADR and the quality of ADR reports needs to be improved.