CGRP、NO和ET在甘油所致大鼠急性肾功能衰竭中的变化及氨氯地平对其的影响

目的：观察甘油所致急性肾功能衰竭（ARF）大鼠血浆降钙素基因相关肽（CGRP）、一氧化氮（NO）和内皮素（ET）的变化及钙通道阻滞剂（CCB）氨氯地平对其的影响。方法：检测正常和甘油所致ARF大鼠不同时间血浆CGRP、ET和血清NO水平的变化，并观察应用氨氯地平对肾脏功能及血浆CGRP，ET和血清NO的影响。结果：甘油所致ARF大鼠血浆CGRP、NO水平明显降低（P＜0．01，P＜0．05）；血浆ET明显升高（P＜0．05），氨氯地平治疗组肾损害减轻（P＜0．05），CGRP、NO显著升高（P＜0．01，P＜0．05）而ET明显降低（P＜0．05）。结论：CGRP、NO的降低和ET的升高可能参与甘油所致ARF的形成和进展，氨氯地平对肾脏功能保护作用可能与其升高CGRP、NO和降低ET有关。

Plasma calcitonin gene-related peptide, endothelin and serum nitric oxide levels in rats with glycerol-induced acute renal failure and effect of amlodipine on them

Objective: To investigate plasma calcitonin gene-related peptide (CGRP), endothelin(ET) and serum nitric oxide (NO) levels in rats with glycerol-induced acute renal failure (ARF) and effect of amlodipine on them. Methods: Plasma CGRP,ET and serum NO levels of glycerol-induced ARF rats with or without treatment with amlodipine were measured. Results: Plasma CGRP and serum NO levels of ARF rats decreased and plasma ET increased. Treatment with amlodipine improved the kidney injuries. Plasma CGRP and serum NO levels increased significantly (P<0.01,P<0.05) and plasma ET markedly decreased(P<0.05). Conclusion: Decreased plasma CGRP,NO and increased ET may play a role in the development of glycerol-induced ARF. The protection of amlodipine on renal function may be through the increase of CGRP,NO and the decrease of ET.