| 腺苷-磷酸激活蛋白激酶激活剂研究进展 |
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| 引用本文： | 徐亚洲,廖红,张陆勇,李佳,庞涛.腺苷-磷酸激活蛋白激酶激活剂研究进展[J].药学进展,2014(2):125-131. |
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| 作者姓名： | 徐亚洲 廖红 张陆勇 李佳 庞涛 |
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| 作者单位： | [1]中国药科大学新药筛选中心,江苏南京210009 [2]中国科学院上海药物研究所,国家新药筛选中心,上海201203 |
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| 摘 要： | 腺苷—磷酸激活蛋白激酶（AMPK）是调控能量代谢的重要激酶，在代谢障碍、心血管疾病及肿瘤等疾病的病理进程中都有重要的调节作用。对AMPK的结构及其生理调节作用进行介绍，并重点综述AMPK间接激活剂和直接激活剂的研究进展，旨在为AMPK激活剂的深入开发提供参考。
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| 关 键 词： | 腺苷—磷酸激活蛋白激酶 间接激活剂j直接激活剂 |
Advances in Research on AMPK Activators |
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| XU Yazhou,LIAO Hong,ZHANG Luyong,LI Jia,PANG Tao.Advances in Research on AMPK Activators[J].Progress in Pharmaceutical Sciences,2014(2):125-131. |
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| Authors: | XU Yazhou LIAO Hong ZHANG Luyong LI Jia PANG Tao |
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| Institution: | 1. New Drug Screening Center, China Pharmaceutical University, Nanjing e t OOOg, China; 2. National Center for Drug Screening, Shanghai Institute of Maleria Medica, Chinese Academy of Sciences, Shanghai 201203, China) |
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| Abstract: | Adenosine 5＇-monophosphate-activated protein kinase （AMPK） is a key .nlayer in regulating energy metabolism. It is placed at the center stage in studies of many pathological conditions including metabolic disorders, cardiovascular disease and cancer.The structure and physiological regulation of AMPK have been introduced in this paper. Moreover, the research progresses in indirect and direct activators of AMPK have been especially reviewed, so as to provide insights for the further development of this kind of drugs. |
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| Keywords: | AMPK indirect activator direct activator |
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