超敏C反应蛋白在川崎病患儿疗效监测中的应用

目的检测川崎病(KD)患儿超敏C反应蛋白(hs-CRP)水平变化,探讨测定KD患儿hs-CRP对丙种球蛋白治疗反应的临床意义。方法于2008年1月至2009年5月分别对广州儿童医院和中山大学附属第二医院儿科收治的65例KD患儿(其中38例合并冠状动脉扩张,6例形成动脉瘤,21例合并冠状动脉异常)在静脉给予丙种球蛋白治疗前后测定其hs-CRP、白细胞(WBC)、血红蛋白(Hb)、血小板(PLT)及红细胞沉降率(ESR)。结果 65例KD患儿静脉应用丙种球蛋白后hs-CRP迅速下降至正常,与治疗前比较差异有统计学意义(P0.01)。结论动态观察hs-CRP水平有助于对KD患儿给予静脉丙种球蛋白治疗有无反应的早期判断。

Clinical significance of serum high sensitive C-reactive protein monitoring curative effect in children with Kawasaki disease

Objective To investigate the clinical significance of the variability of serum C-reactive protein（CRP） level in children with Kawasaki disease（KD）.Methods The counts of WBC,Hb,PLT,ESR and hs-CRP were performed before and after treatment with intravenous immunoglobulin in 65 cases of Kawasaki Disease（including 35 cases with coronary arteries dilation,6 cases with coronary artery lesions and 21 cases with abnormal coronary artery）in Guangzhou Paediatrics Hospital and our hospital.Results There was significant difference （P〈0.01） in hs-CRP level among the three groups before and after treatment by intravenous immunoglobulin.Conclusion Observation of the hs-CRP level change is helpful to judge whether the KD children response to the immunoglobulin treatment in early time.