Methylphenidate effects on activity-stress gastric lesions and regional brain noradrenaline metabolism in rats |
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| Authors: | G B Glavin |
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| Affiliation: | 1. Dept. of Psychology, University of Winnipeg, Winnipeg, Canada R3B 2E9;2. Dept. of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba Winnipeg, Canada R3E 0W3 |
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| Abstract: | Methylphenidate (5, 10, or 20 mg/kg/day) or saline were administered to rats in the activity-stress ulcer paradigm. Running-wheel activity and food consumption did not differ among groups. Methylphenidate produced dose-related increases in gastric ulcer severity, decreases in hypothalamic noradrenaline (NA) and increases in 3-methoxy-4-hydroxy-phenylethyleneglycol sulfate (MHPG-SO4) in the hypothalamus, amygdala, hippocampus and thalamus. These results differ markedly from the effects seen with a related substance, d-amphetamine, and suggest different mechanisms of action for these drugs. |
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| Keywords: | Methylphenidate Stress Ulcer Noradrenaline 3-Methoxy-4-hydroxy-phenylethyleneglycol sulfate |
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