痰湿型多囊卵巢综合征临床及内分泌特征分析

目的：探讨多囊卵巢综合征痰湿证临床及内分泌特征性指标,从而为多囊卵巢综合征的中医规范化诊治提供依据。方法：以45例正常育龄妇女为对照组,135例PCOS患者分为两组：非痰湿组、痰湿组,其中非痰湿组85例,痰湿组50例,化学发光法测定血清性激素水平及DHEA-S、FPG、FINS、SHBG水平。分别比较3组初潮年龄、月经周期、BMI、腰围、SBP、DBP等临床指标的差异性,3组血清性激素水平及DHEA-S、SHBG、FPG、FINS、HOMA-IR及FTI水平的差异性。结果：（1）各组间临床特征比较：月经周期PCOS两组与对照组比较均有显著性差异（P〈0.05）;BMI、腰围PCOS痰湿组与对照组及非痰湿组比较均有显著性差异（P〈0.05）。（2）各组间性激素及DHEA-S的比较：LH、T值PCOS两组与对照组比较均有显著性差异（P〈0.05）;DHEA-S值PCOS非痰湿组与对照组比较有显著性差异（P〈0.05）,PCOS痰湿组与对照组比较有极显著性差异（P〈0.01）,PCOS痰湿组与PCOS非痰湿组比较也有显著性差异（P〈0.05）。（3）各组间胰岛素抵抗相关参数及SHBG、FTI的比较：FINS、HOMA-IR、SHBG、FTI值PCOS痰湿组与对照组比较有极显著性差异（P〈0.01）,PCOS痰湿组与PCOS非痰湿组比较也有显著性差异（P〈0.05）。结论：多囊卵巢综合征痰湿证在BMI、腰围、DHEA-S、SHBG、FPG、FINS、HOMA-IR及FTI等水平具有特征性表达,胰岛素抵抗相关指标可以作为其客观诊断依据之一。

Analysis of Clinical and Endocrinal Characteristics of Polycystic Ovary Syndrome with Phlegm-dampness

Objective：To explore the characteristic index of PCOS patients with phlegm-dampness in order to give further basis on standardized diagnosis and treatment of PCOS.Methods：45 normal reproductive-aged women as controls,and 135 PCOS patients were divided into two groups：phlegmdampness group and non phlegm-dampness group.Serum sex hormone,as well as DHEA-S,FPG,FINS,SHBG levels were measured by Chemiluminescence.Indeics above and other parameters（menstrual cycle,BMI,waist size,Homa-IR,FTI etc were compared among groups.Results：（1） Clinical characteristics：menstrual cycle：PCOS groupscontrol;BMI,waist size：phlegm-dampness PCOS groupcontrol,phlegmdampness PCOS groupnon phlegm-dampness group（P〈0.05） .（2） Sex hormone and DHEA-S：LH,T levels：PCOS groupscontrol,DHEA-S level：phlegm-dampness PCOS groupcontrol（P〈0.01） ,phlegmdampness PCOS groupnon phlegm-dampness group（P〈0.05） .（3） IR related parameters：FINS,HOMAIR,FTI：phlegm-dampness PCOS groupcontrol（P〈0.01） ,phlegm-dampness PCOS groupnon phlegmdampness group（P〈0.05） ;SHBG level：phlegm-dampness PCOS groupcontrol（P〈0.01） ,phlegmdampness PCOS groupnon phlegm-dampness group（P〈0.05） .Conclusions：There were characteristic expression on BMI,waist size,DHEA-S,SHBG,FPG,FINS,HOMA-IR and FTI levels in phlegmdampness PCOS patients,they might be one of objective diagnosis basis of phlegm-dampness PCOS patients.