桑枝总黄酮提取物对2型糖尿病大鼠的作用研究

目的：观察桑枝总黄酮提取物对2型糖尿病大鼠的空腹血糖、糖化血清蛋白及胰岛素抵抗的影响,探究其可能的作用机制。方法：采用高糖高脂饮食加小剂量链脲菌素建立2型糖尿病大鼠模型,灌胃给药14天后测定空腹血糖（FPG）、糖化血清蛋白（GSP）、空腹胰岛素（FINS）,计算胰岛素敏感性指数（ISI）等。结果：桑枝总黄酮提取物能够明显降低2型糖尿病大鼠血糖、糖化血清蛋白,提高胰岛素敏感性指数,与对照组相比,差异具有统计学意义（P〈0.01）。结论：桑枝总黄酮提取物可降低2型糖尿病大鼠血糖并能够改善IR。

Study on the Effects of Mulberry Falconoid Extract on Rats with Type 2 Diabetes

Objective：To observe the effects of mulberry falconoid extract on the fasting blood glucose,glycosylated serum protein and insulin resistance of rats with type 2 diabetes and to explore its possible mechanism.Methods：The model of Type 2 diabetic rats is established by offering high glucose and high fat diet plus low-dose streptozotocin.After the rats have taken the medicine for 14 days,we start to measure its fasting plasma glucose（FPG） ,glycosylated serum protein（GSP） ,fasting insulin（FINS） ,and calculate the insulin sensitivity index（ISI） ,ect.Results：The mulberry flavonoids extract can significantly lower blood glucose,glycosylated serum protein,and improve insulin sensitivity index.Compared with the control group,the difference is of statistical significance（P〈0.01） .Conclusion：The mulberry falconoid extract can reduce blood glucose and improve IR of rats with type 2 diabetes.