| 椒枝软胶囊的质量控制研究 |
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| 引用本文： | 蒋剑平,陈华,许家鸾,盛振华,宋康. 椒枝软胶囊的质量控制研究[J]. 中华中医药杂志, 2012, 0(5): 1401-1403 |
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| 作者姓名： | 蒋剑平 陈华 许家鸾 盛振华 宋康 |
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| 作者单位： | 浙江省中医院;浙江中医药大学 |
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| 基金项目： | 浙江省科技计划重大项目(No.2008C13005);浙江省教育厅科研项目(No.Y200906284)~~ |
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| 摘 要： | 目的:建立椒枝软胶囊的质量控制标准。方法:采用薄层色谱法(TLC)法对椒枝软胶囊中的亚麻酸、重楼皂苷进行鉴别;采用高效液相色谱法(HPLC)法对椒枝软胶囊中的重楼皂苷Ⅰ、Ⅱ进行定量测定。结果:在TLC谱图中能检出亚麻酸、重楼皂苷的特征斑点;HPLC法测得重楼皂苷Ⅰ在0.4908-4.908μg线性关系良好(r=0.9999),平均回收率为99.42%,RSD为1.36%;重楼皂苷Ⅱ在0.4276-4.276μg线性关系良好(r=0.9998),平均回收率为101.00%,RSD为1.52%。结论:该方法准确、灵敏,重现性好,能有效地控制椒枝软胶囊的质量。
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| 关 键 词： | 椒枝软胶囊 质量标准 薄层色谱法 高效液相色谱法 重楼皂苷Ⅰ 重楼皂苷Ⅱ |
Quality control for Jiaozhi Soft Capsula |
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| JIANG Jian-ping,CHEN Hua,XU Jia-luan,SHENG Zhen-hua,SONG Kang. Quality control for Jiaozhi Soft Capsula[J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2012, 0(5): 1401-1403 |
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| Authors: | JIANG Jian-ping CHEN Hua XU Jia-luan SHENG Zhen-hua SONG Kang |
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| Affiliation: | 1(1Zhejiang Hospital of TCM,Hangzhou 310006,China;2Zhejiang Chinese Medical University,Hangzhou 310053,China) |
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| Abstract: | Objective: To establish the quality control standard of Jiaozhi Soft Capsule.Methods: Zanthoxylum seed oil and Chonglou saponin were identified by TLC.HPLC was used to determine Chonglou saponinⅠand Chonglou saponinⅡof Jiaozhi Soft Capsule.Results: Linolenic acid and Chonglou saponin could be identified by TLC.Chonglou saponinⅠshowed a good linear relationship at a range of 0.4908-4.908μg,r=0.9998,the average recovery was 99.42 %,and RSD was 1.36%.Chonglou saponin Ⅱshowed a good linear relationship at a range of 0.4276-4.276μg,r=0.9999,the average recovery was 101.00%,and RSD was 1.52%.Conclusion: The method is accurate with the good reproducibility and can be used for the quality control of Jiaozhi Soft Capsule. |
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| Keywords: | Jiaozhi Soft Capsula Quality standard TLC HPLC Paris polyphylla saponinⅠ Paris polyphylla saponinⅡ |
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