| 修复基因XRCC1 Arg280His多态性在肝癌发病机制中的研究 |
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| 引用本文： | 薄挽澜,张贵贤,李冬月,王玺. 修复基因XRCC1 Arg280His多态性在肝癌发病机制中的研究[J]. 哈尔滨医科大学学报, 2012, 46(1): 43-45 |
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| 作者姓名： | 薄挽澜 张贵贤 李冬月 王玺 |
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| 作者单位： | 1. 哈尔滨医科大学附属第一医院 消化内科,黑龙江 哈尔滨,150001
2. 天津市传染病院,天津,310000 |
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| 基金项目： | 黑龙江省教育厅资助项目 |
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| 摘 要： | 目的探讨DNA损伤修复基因XRCC1多态与肝癌遗传易感性的关系。方法选取了90例肝癌患者及90例正常自愿对照者进行研究,采用限制性片段长度多态性方法,比较不同基因型与肝癌发病的关系。结果变异型等位基因XRCC1 Arg/His及His/His的出现率在肝癌组和对照组中分别为28.89%和13.33%,P<0.05;而野生基因型XRCC1 Arg/Arg出现率在肝癌组和对照组中分别为71.11%和86.67%,P>0.05。结论 XRCC1基因Arg280His单核苷酸多态在肝癌的发生机制中起着至关重要的作用。
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| 关 键 词： | 肝癌 XRCC1 基因多态性 |
Study of polymorphisms of DNA repair gene XRCC1 and hepatic cancer |
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| BO Wan-lan , ZHANG Gui-xian , LI Dong-yue , WANG Xi. Study of polymorphisms of DNA repair gene XRCC1 and hepatic cancer[J]. Journal of Harbin Medical University, 2012, 46(1): 43-45 |
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| Authors: | BO Wan-lan ZHANG Gui-xian LI Dong-yue WANG Xi |
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| Affiliation: | 1(1.Department of Digestive Diseases,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2.Infectious Diseases Hospital in Tianjin,Tianjin 310000,China) |
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| Abstract: | Objective To evaluate the association between polymorphisms of XRCC1 and risk of hepatic cancer.Methods The polymorphisms of XRCC1 in 90 histological confirmed hepatic cancer patients and 90 free controls were studyed,and the two polymorphisms were genotyped by using polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP).Results The frequency of Arg/His and His/His for variant XRCC1 in cases and controls were 28.89% and 13.33%,respectively,obvious higher in patients than that in controls,P<0.05.But the frequency of Arg/ Arg in cases and controls were 71.11% and 86.67%,P>0.05.Conclusion The XRCC1 Arg280His may contribute to the developing hepatic cancer. |
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| Keywords: | hepatic cancer XRCC1 polymorphism |
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