| Wistar大鼠实验性自身免疫性脑脊髓炎模型的建立 |
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| 引用本文： | 赵亚朴,黄庆军,王沛,刘颖,王憬,郝新玲.Wistar大鼠实验性自身免疫性脑脊髓炎模型的建立[J].白求恩军医学院学报,2003,1(4):200-201,F002. |
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| 作者姓名： | 赵亚朴 黄庆军 王沛 刘颖 王憬 郝新玲 |
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| 作者单位： | 050081,石家庄,白求恩军医学院 |
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| 摘 要： | 目的 研究用牛的髓鞘碱性蛋白(MBP)诱导Wistar大鼠发生实验性自身免疫性脑脊髓炎(EAE)。方法 一次性给Wistar大鼠双后腿足垫皮内注射牛MBP-福氏完全佐剂(CFA)混合乳剂，同时辅以百日咳杆菌。结果 实验组大鼠全部发病，对照组无一发病。结论 用牛脊髓MBP的粗提品可成功地诱导Wistar大鼠发生EAE。
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| 关 键 词： | 髓鞘碱性蛋白 大鼠 实验性自身免疫性脑脊髓炎 多发性硬化症 |
| 文章编号： | 1672-2876(2003)04-0200-02 |
Generation of Experimental Autoimmune Encephalomyelitis Model in Wistar Rats |
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| ZHAO Yapu,HUANG Qingjun,WANG Pei,et al..Generation of Experimental Autoimmune Encephalomyelitis Model in Wistar Rats[J].Journal of Bethune Military Medical College,2003,1(4):200-201,F002. |
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| Authors: | ZHAO Yapu HUANG Qingjun WANG Pei |
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| Institution: | ZHAO Yapu,HUANG Qingjun,WANG Pei,et al.Department of Pathogen Biology,Bethune Military Medical College,Shijiazhuang 050081,China |
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| Abstract: | Objective To induce experimental autoimmune encephalomyelitis (EAE) in Wistar rat treated with myelin basic protein (MBP) purified from cattle spinal cord. Methods Wistar rats were immunized with both MBP in CFA and Bordetelle pertussis. Results All the experimental Wistar rats that treated with MBP and Bordetelle pertussis developed EAE but none of the control group. Conclusion EAE can be induced in less susceptible strains such as Wistar rats by a single intradermal injection of cattle's MBP in CFA. |
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| Keywords: | Myelin basic protein Rat Experimental autoimmune encephalomyelitis Multiple sclerosis |
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