过氧化物酶增殖激活受体γ协同激活因子-1与蒙古族高血压的关系

目的：旨在探讨过氧化物酶增殖激活受体γ协同激活因子-1基因Thr394Thr多态性及Gly482Ser多态性与蒙古族高血压的关系.方法：随机选取蒙古族高血压病人107例,蒙古族正常对照168例.采用聚和酶链反应（PCR）限制性片段长度多态性（RFLP）技术进行基因型检测.结果：①内蒙古地区蒙古族人群中,高血压病患者PGC-1α基因Thr394 Thr多态性的基因型以GG基因型为主,健康对照者PGC-1α基因Thr394Thr多态性的基因型以GA基因型为主,高血压组与正常组相比有显著性差异（P=0.000＜0.05）.②内蒙古地区蒙古族人群中,高血压病患者与健康对照者PGC-1α基因Gly482Ser多态性的基因型均以GA基因型为主,高血压组与正常组相比没有显著性差异（P=0.893＞0.05）.结论：PGC-1α基因Thr394Thr多态性和Gly482Ser多态性存在种族差异,在内蒙古地区蒙古族人群中,PGC-1α基因Thr394 Thr多态性可能是高血压发病的遗传学因素,而Gly482Ser多态性可能与高血压发病无关.

Association Between Peroxisome Proliferator-activated Receptor Gamma Co-activator Factor-1 and Mongolian Hypertension

Objective： This investigation was to investigate the relationship between the peroxisome prolif- eratoractivated receptor γ on activation of factor - 1 gene Thr394Thr polymorphism and Gly482Ser polymorphism and hypertension in Mongolian. Methods： We randomly selected 107 Mongolian cases of hypertensive patients, 168 Mongolian cases of normal control. Using polymerase chain reaction （PCR） restriction fragment length polymorphism （RFLP） technology to genotype testing. Results：①In the Mongolian population of the Inner Mongolia, PGC- 1a gene Thr394Thr polymorphism genotype of the hypertensive patients is GG - based, PGC- la gene Thr394Thr polymorphism genotype of the healthy controls is GA- based. There is Significant difference between the high blood pressure group and the normal group（P = 0. 000〈 0.05）; ②In the Mongolian population of the Inner Mongolia, PGC- 1a gene Gly482Ser polymorphism genotype of the hypertensive patients and healthy controls is GA- based. There is no difference between the high blood pressure group and the normal group（P = 0. 893 〉 0.05）. Conclusions： PGC -1a gene Thr394Thr polymorphism and PGC - 1a gene Gly482Ser polymorphism have ethnic differences. In the Mongolian population of the Inner Mongolia, PGC- 1a gene Thr394Thr polymorphism may be the genetic factors of the hypertension, while Gly482Ser polymorphism may be have nothing to do with hypertension.