An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia |
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| Authors: | J K Rybakowski A Borkowska P M Czerski P Kapelski M Dmitrzak-Weglarz J Hauser |
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| Institution: | (1) Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland;(2) Clinical Neuropsychology Unit, Nicolaus Copernicus University Torun, Collegium Medicum Bydgoszcz, Poland;(3) Laboratory of Psychiatric Genetics, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland |
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| Abstract: | Summary. Dopamine (DA), an important neurotransmitter in prefrontal cortex (PFC), is involved in the pathogenesis of schizophrenia.
The aim of the study was to test an association between common polymorphism of genes for DA receptors DRD1, DRD2, DRD3, DRD4,
and performance on the Wisconsin Card Sorting Test (WCST), measuring various functions of PFC, in 138 schizophrenic patients.
Patients with G/G genotype of DRD1 tended to obtain worse results in all domains of WCST compared to patients with remaining
genotypes, particularly for number of completed corrected categories, and trials to set the first category. A relationship
was also found in female patients between DRD2 polymorphism and number of perseverative errors, while no association between
WCST results and DRD3 or DRD4 polymorphism was observed in patients studied. The results may suggest an association between
DRD1 gene polymorphism and performance on PFC test in schizophrenia. Also, the gender-dependent role of DRD2 in this process
may be presumed. |
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| Keywords: | : Schizophrenia dopaminergic receptors D1 D2 D3 D4 Wisconsin Card Sorting Test prefrontal cortex |
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