| 结直肠癌患者血清叶酸和粪便短链脂肪酸的变化及意义 |
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| 引用本文： | 赵海霞,彭贵勇,房殿春.结直肠癌患者血清叶酸和粪便短链脂肪酸的变化及意义[J].胃肠病学和肝病学杂志,2011,20(1):55-57. |
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| 作者姓名： | 赵海霞 彭贵勇 房殿春 |
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| 作者单位： | 第三军医大学西南医院消化科,重庆,400038 |
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| 基金项目： | 国家“十一五”卫生公益行业科研基金项目资助(200802094) |
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| 摘 要： | 目的探讨结直肠癌患者血清叶酸和粪便短链脂肪酸的变化及意义。方法收集400例经肠镜检查结果正常者、58例结直肠癌和56例腺瘤性息肉病人的血液和大便标本,用磁性颗粒化学发光免疫法检测血清叶酸水平,高压液相色谱法检测大便短链脂肪酸,非秩和检验方法进行数据分析。结果从总体上看,正常组、腺瘤性息肉组、结直肠癌组血清叶酸、大便短链脂肪酸浓度无显著性差异（叶酸P=0.199,短链脂肪酸P=0.214）,提示两者与结直肠癌和腺瘤性息肉发生风险无关。经多独立样本两两比较法（Nemenyi法）检验,结直肠癌组的异丁酸值要显著高于正常组（P=0.002）,而与腺瘤性息肉组无显著性差异（P=0.194）;腺瘤性息肉组和结直肠癌组的异戊酸值显著高于正常组（P=0.016和P=0.000）,而腺瘤性息肉组与结直肠癌组的异戊酸值无显著性差异。结论血清叶酸和粪便纤维素的代谢产物-大便短链脂肪酸与结直肠癌和腺瘤性息肉的发生无关。
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| 关 键 词： | 血清叶酸 短链脂肪酸 结直肠癌 腺瘤性息肉 |
Levels of serum folate and fecal short chain fatty acid in patients with colorectal cancer |
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| ZHAO Haixia,PENG Guiyong,FANG Dianchun.Levels of serum folate and fecal short chain fatty acid in patients with colorectal cancer[J].Chinese Journal of Gastroenterology and Hepatology,2011,20(1):55-57. |
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| Authors: | ZHAO Haixia PENG Guiyong FANG Dianchun |
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| Institution: | ZHAO Haixia,PENG Guiyong,FANG Dianchun Department of Gastroenterology,Southwest Hospital,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | Objective To investigate the changes of levels of serum folate and fecal short chain fatty acid(SCFA) in patients colorectal cancer(CRC).Methods Four hundred cases of normal controls,58 cases of colorectal cancer and 56 cases of adenomatous polyp identified through endoscopy were included in this study.Levels of serum folate and fecal SCFA were measured by chemiluminescence immunoassay and high pressure liquid chromatography.Results There was no significant difference in levels of serum folate and fecal sho... |
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| Keywords: | Serum folate Fecal short chain fatty acid Colorectal cancer Adenomatous polyp |
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