A Comparative Study of the Burn Wound Healing Properties of Saline-Soaked Dressing and Silver Sulfadiazine in Rats |
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Authors: | Hemmat Maghsoudi Siavash Monshizadeh Mehran Mesgari |
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Institution: | (1) Department of surgery, Faculty of Medicine, University of medical sciences of Tabriz, Tabriz, Iran;(2) The Sina Hospital, Azadi Street, P.O. Box 1548, Tabriz, 5163639888, East Azarbaijan, Iran |
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Abstract: | The purpose of this study was to further investigate that phenomenon and to explore the effect silver sulfadiazine on wound
healing. Full-thickness burn wounds were created on the dorsum of Wistar albino rats under anesthesia. The wounds were treated
with silver sulfadiazine and saline-soaked dressing for fourteen days, and then observed until healed. Wound surface area
was measured each three days. Time to 50% and 90% healing was compared. No clinical infections occurred. Wound half-life and
healing times were shortest in the saline-soaked group (P < 0.0001) in full-thickness burns. Wound contraction was delayed by silver sulfadiazine. These data suggest that silver sulfadiazine
retard burn wound healing. Infection control without delay of burn wound healing is most appealing and clinical trials are
planned. |
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Keywords: | Silver sulfadiazine Saline-soaked dressing Burn wounds care |
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