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Possible Involvement of Prostaglandins in Increases in Rat Plasma Adrenocorticotropic Hormone and Corticosterone Levels Induced by Radiation and Interleukin-1{alpha} Alone or Combined
Authors:KANDASAMY, SATHASIVA B.   THIAGARAJAN, ARUN B.   HARRIS, ALAN H.
Affiliation:*Behavioral Sciences Department, Armed Forces Radiobiology Research Institute Bethesda, Maryland 20889-5603 "{dagger}"Section Neurochemistry, National Institute on Alcohol Abuse and Alcoholism Bethesda, Maryland 20892-5145

Received February 8, 1994; accepted September 28, 1994

Abstract:Exposing rats to 1–10 Gy of ionizing radiation increasedplasma adrenocorticotropic hormone (ACTH) and corticoste-rone(CORT) levels. In both irradiated and nonirradiated rats, recombinanthuman interleukin-1{alpha} (rhIL-1{alpha} 1 hr before radiation/sham exposure)enhanced plasma ACTH and CORT levels. Indomethacin, a cyclooxygenaseinhibitor, attenuated plasma ACTH and CORT levels induced byradiation. Indomethacin also attenuated ACTH and CORT levelsinduced by radiation and interleukin-1{alpha} alone or combined. Theseresults suggest that prostaglandins are involved in the increasein plasma ACTH and CORT levels induced by radiation and rhIL-1{alpha}alone or combined.
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