Possible Involvement of Prostaglandins in Increases in Rat Plasma Adrenocorticotropic Hormone and Corticosterone Levels Induced by Radiation and Interleukin-1{alpha} Alone or Combined期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Possible Involvement of Prostaglandins in Increases in Rat Plasma Adrenocorticotropic Hormone and Corticosterone Levels Induced by Radiation and Interleukin-1{alpha} Alone or Combined

Authors:	KANDASAMY SATHASIVA B; THIAGARAJAN ARUN B; HARRIS ALAN H

Institution:	^*Behavioral Sciences Department, Armed Forces Radiobiology Research Institute Bethesda, Maryland 20889-5603 ${dagger}$ Section Neurochemistry, National Institute on Alcohol Abuse and Alcoholism Bethesda, Maryland 20892-5145 Received February 8, 1994; accepted September 28, 1994

Abstract:	Exposing rats to 1–10 Gy of ionizing radiation increasedplasma adrenocorticotropic hormone (ACTH) and corticoste-rone(CORT) levels. In both irradiated and nonirradiated rats, recombinanthuman interleukin-1 ${alpha}$ (rhIL-1 ${alpha}$ 1 hr before radiation/sham exposure)enhanced plasma ACTH and CORT levels. Indomethacin, a cyclooxygenaseinhibitor, attenuated plasma ACTH and CORT levels induced byradiation. Indomethacin also attenuated ACTH and CORT levelsinduced by radiation and interleukin-1 ${alpha}$ alone or combined. Theseresults suggest that prostaglandins are involved in the increasein plasma ACTH and CORT levels induced by radiation and rhIL-1 ${alpha}$ alone or combined.

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