| 前胡香豆素B和前胡香豆素C的分离和鉴定 |
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| 引用本文： | 孔令义,裴月湖,李铣,王素贤,侯柏玲,朱廷儒. 前胡香豆素B和前胡香豆素C的分离和鉴定[J]. 药学学报, 1993, 28(10): 772-776 |
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| 作者姓名： | 孔令义 裴月湖 李铣 王素贤 侯柏玲 朱廷儒 |
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| 作者单位： | 沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室，沈阳药学院天然药物研究室 沈阳 110015 中国药科大学 南京 210009，沈阳 110015，沈阳 110015，沈阳 110015，沈阳 110015，沈阳 110015 |
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| 摘 要： | 从中药白花前胡(Peucedanum praeruptorum)根中分离和鉴定了5个化合物,经理化常数测定,波谱数据解析及化学反应,分别鉴定为3′-angeloyloxykhellactone(Ⅸ)、前胡香豆素B(Ⅹ)、前胡香豆素C(Ⅺ)、Pd-Ⅲ(ⅩⅢ)和peucedanocoumarin Ⅲ(ⅩⅤ)。其中化合物Ⅹ和Ⅺ为两个新化合物,通过和凯林内酯的化学沟通确定了其绝对构型。其化学结构分别为3′(S)-乙酰氧基-4′(S)-羟基-3′,4′-二氢邪蒿内酯(Ⅹ)和3′(S)-羟基-4′(S)-乙酰氧基-3′,4′-二氢邪蒿内酯(Ⅺ)。Ⅸ为首次报道自天然物中分得。
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| 关 键 词： | 白花前胡 前胡香豆素B 前胡香豆素C |
| 收稿时间： | 1992-11-18 |
THE ISOLATION AND IDENTIFICATION OF QIANHUCOUMARIN B AND QIANHUCOUMARIN C FROM PEUCEDANUM PRAERUPTORUM |
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| LY Kong,YH Pei,X Li,SX Wang,BL Hou and TR Zhu. THE ISOLATION AND IDENTIFICATION OF QIANHUCOUMARIN B AND QIANHUCOUMARIN C FROM PEUCEDANUM PRAERUPTORUM[J]. Acta pharmaceutica Sinica, 1993, 28(10): 772-776 |
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| Authors: | LY Kong YH Pei X Li SX Wang BL Hou TR Zhu |
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| Abstract: | Five compounds were isolated from the traditional Chinese medicine Qianhu, roots of Peucedanum praeruptorum. Their structures were identified as 3'-angeloyloxykhellactone (Ⅸ), qianhucoumarin B (Ⅹ), qianhucoumarin C (Ⅺ), Pd-Ⅲ (ⅫⅠ)and peucedanocoumarin Ⅲ(ⅩⅤ). Among them, Ⅹ and Ⅻ are new compounds, their absolute configurations were elucidated by chemical correlation with khellactones, as 3' (S)-acetoxy-4' (S)-hydroxy-3', 4'-dihydroseselin(Ⅹ) and 3' (S)-hydroxy-4' (S)-acetoxy-3', 4'-dihydroseselin (Ⅺ). Compound Ⅸ was isolated from plants for the first time. |
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| Keywords: | Qianhucoumarin B Qianhucoumarin C 3′-Angeloy-loxykhellactone Peucedanum praeruptorum |
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