膝关节软骨下立柱式自体骨移植后软骨的变化

目的 通过观察兔膝关节软骨下立柱式自体骨移植的软骨的变化，探讨移植后关节软骨塌陷及软骨退变的原因。方法 ４２只大耳白兔为实验对象，随机分为Ａ、Ｂ两组。分别建立保留不同厚度的关节软骨下大块骨缺损的动物模型，采用立柱式自体额骨移植。分别于术后第１、１２周处死１０只、３２只动物，切取标本。应用光镜、透射电镜，对实验动物的软骨进行形态学观察。结果 Ａ组平均残留软骨下骨的厚度为１．４２ｍｍ，１周时软骨下骨未

Changes of Articular Cartilage after Subchondral Replacement with Autogenous Bone in Rabbits'Knee Joint

Objective To explore the reason of cartilage collapsing and degenerate after subchondral replacement with autogenous bone, in defects in medial tibial condyles of rabbits. Methods 42 rabbits were divided into two groups, according to the reserved thickness of subchondral bone. Subchondral defects in animal models were replacement with columnar bone. Results Group A: the thickness of reserved Subchondral bone was 1.42mm. No necrosis came out at 1 week, no collapse in cartilage at 12 weeks. 12.5% articular cartilage degenerated. Group B: the thickness was 0.86mm. 43.7% cartilage degenerated. Conclusions Curetting of subchondral bone extensively will carry a high risk of postoperative cartilage degeneration. Columnar replacement with autogenous bone will recover bone defect under articular cartilage quiet well.