| 幽门螺杆菌感染、端粒酶活性与胃癌、癌前病变关系的研究 |
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| 引用本文： | 伍冬梅,李春鸣,张赟. 幽门螺杆菌感染、端粒酶活性与胃癌、癌前病变关系的研究[J]. 重庆医学, 2011, 40(14): 1386-1387,1390,1458. DOI: 10.3969/j.issn.1671-8348.2011.14.013 |
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| 作者姓名： | 伍冬梅 李春鸣 张赟 |
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| 作者单位： | 伍冬梅,Wu Dongmei(遵义医学院组胚教研室,贵州遵义,563003);李春鸣,Li Chunming(遵义医学院病理教研室,贵州遵义,563003);张赟,Zhang Yun(贵州省人民医院病理科,贵阳,550002) |
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| 摘 要： | 目的 探讨幽门螺杆菌(Hp)、端粒酶在胃癌及癌前病变中的作用及相互关系.方法 应用Warthin-Starry银染法、免疫组织化学SP法及核酸原位杂交技术分别检测66例胃黏膜肠化生、36例异型增生、50例胃癌及10例正常胃黏膜Hp感染情况、hTERT蛋白及hTERT mRNA的表达情况.结果 胃黏膜肠化生、异型增生及胃...
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| 关 键 词： | 胃肿瘤 癌前状态 螺杆菌,幽门 端粒,末端转移酶 |
Relationship between infection of Helicobacter pylori and telomerase activity in gastric cancer and precancerous lesions |
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| Wu Dongmei,Li Chunming,Zhang Yun. Relationship between infection of Helicobacter pylori and telomerase activity in gastric cancer and precancerous lesions[J]. Chongqing Medical Journal, 2011, 40(14): 1386-1387,1390,1458. DOI: 10.3969/j.issn.1671-8348.2011.14.013 |
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| Authors: | Wu Dongmei Li Chunming Zhang Yun |
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| Affiliation: | 1.Department of Histology and Embryology,Zunyi Medical College,Zunyi 563003,China;2.Department of Pathology,Zunyi Medical College,Zunyi 563003,China;3.Department of Pathology,Guizhou Provincial People′s Hospital,Guiyang 550002,China) |
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| Abstract: | Objective To study the effect and correlation of infection of Helicobacter pylori and telomerase activity in gastric cancer,precancerous lesions.Methods Hp infection was detected by Warthin-Starry method,hTERT protein expression was examined by immunohistochemical technique SP,hTERT mRNA expression was examined by situ hybridization.Results Hp infection,the positive expression rate of hTERT protein and hTERT mRNA in intestnal metaplasia,epithelial dysplasia of stomach and gastric carcinomas were significant... |
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| Keywords: | stomach neoplasms precancerous conditions helicobacter pylori telomerase |
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