| IL-6和PIAS3与肝硬化大鼠肝部分切除后肝再生的关系 |
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| 引用本文： | 袁晟光,温江涛,吕军,农卡特,张明慧,杨波.IL-6和PIAS3与肝硬化大鼠肝部分切除后肝再生的关系[J].重庆医学,2011,40(14):1373-1375. |
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| 作者姓名： | 袁晟光 温江涛 吕军 农卡特 张明慧 杨波 |
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| 作者单位： | 袁晟光,温江涛,吕军,农卡特,杨波,Yuan Shengguang,Wen Jiangtao,Lv Jun,Nong Kate,Yang Bo(桂林医学院附属医院肝胆外科,广西桂林,541001);张明慧,Zhang Minghui(广西医科大学附属肿瘤医院麻醉科,南宁,530021) |
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| 基金项目： | 广西科学研究与技术开发计划应用基础研究专项基金资助课题 |
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| 摘 要： | 目的研究IL-6和PIAS3在肝硬化大鼠肝部分切除后的变化规律与肝脏再生的关系。方法实验分为肝硬化切除组(E组)和正常肝切除组(C组),观察比较术后0、1、2、4、12、24、48、72 h肝再生率、增殖细胞核抗原(PCNA)及肝组织IL-6 mR-NA、PIAS3 mRNA的表达。结果术后72 h E组肝再生率明显低于C组(P<0.05);E组PCNA的表达在12 h前均高于C组,呈缓慢上升趋势,于48 h达高峰,但远低于C组;E组IL-6 mRNA水平缓慢升高,峰值延迟,且远低于C组峰值;C组PIAS3 mR-NA的水平于术后4 h开始下降,而E组于术后12 h开始下降,且E组术后0~12 h均高于C组(P<0.05)。结论硬化肝脏部分切除术后肝再生障碍机制与IL-6和PIAS3表达失衡有关。
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| 关 键 词： | 白细胞介素-6 活化STAT的蛋白抑制物 肝硬化 肝再生 |
Relationship of IL-6 and PIAS3 with liver regeneration in cirrhotic rats after partial hepatectomy |
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| Yuan Shengguang,Wen Jiangtao,Lv Jun,Nong Kate,Zhang Minghui,Yang Bo.Relationship of IL-6 and PIAS3 with liver regeneration in cirrhotic rats after partial hepatectomy[J].Chongqing Medical Journal,2011,40(14):1373-1375. |
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| Authors: | Yuan Shengguang Wen Jiangtao Lv Jun Nong Kate Zhang Minghui Yang Bo |
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| Institution: | Yuan Shengguang1,Wen Jiangtao1,Lv Jun1,Nong Kate1,Zhang Minghui2,Yang Bo1(1.Department of Hepatobiliary Surgery,Affiliated Hospital of Guilin Medical College,Guilin,Guangxi 530021,China,2.Department of Anesthesiology,Affiliated Tumor Hospital,Guangxi Medical University,Naning,China) |
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| Abstract: | Objective To explore the change of IL-6 and PIAS3 and their correlation with liver regeneration in cirrhotic rats after partial hepatectomy.Methods SD rats were randomized into 2 groups:group E(cirrhotic rats receiving hepatectomy group)and group C(normal rats receiving hepatectomy group).We determined liver regeneration rate and expression of proliferating cell nuclear antigen(PCNA),IL-6 mRNA and PIAS3 mRNA in liver tissue at 0,1,2,4,12,24,48,72 h after operation.Results The liver regeneration rate after p... |
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| Keywords: | interleukin-6 protein inhibitors of activated STAT liver cirrhosis liver regeneration |
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