| 脑胶质瘤ADC值及H~1-波谱与病理分级的相关性研究 |
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| 引用本文： | 崔建和,柏根基,郭莉莉.脑胶质瘤ADC值及H~1-波谱与病理分级的相关性研究[J].重庆医学,2011,40(14). |
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| 作者姓名： | 崔建和 柏根基 郭莉莉 |
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| 作者单位： | 南京医科大学附属淮安第一医院影像中心,江苏淮安,223300 |
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| 基金项目： | 南京医科大学校基金资助项目，淮安市科技局资助项目 |
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| 摘 要： | 目的 探讨磁共振扩散加权成像(DWI)的表观弥散系数(ADC)值和H1-波谱(H1-MRS)对脑胶质瘤的诊断价值.方法 对43例病理证实的胶质瘤患者进行MRI平扫、增强、DWI和H1-MRS,分别测量肿瘤的实质部分、坏死囊变区、周边区域及对侧相应部位正常脑白质的ADC值和相对ADC值,同时测量脑胶质瘤中的多种化学成分,并与术后病理检查结果进行对照.结果 (1)低级胶质瘤(Ⅰ～Ⅱ级)组的肿瘤实质部分的平均ADC值和rADC值均明显高于高级胶质瘤(Ⅲ～Ⅳ级)组(P<0.01).(2)胶质瘤实质部分的ADC值和rADC值均与肿瘤组织的病理分级呈明显负相关(r=-0.767和-0.792,均P<0.01);(3)高级别、低级别脑胶质瘤的肿瘤组织NAA/Cho、NAA/Cr、Cho/Cr比值差异有统计学意义(P<0.01);高、低级别脑胶质瘤的肿瘤组织分别与对侧正常脑组织NAA/Cho、NAA/Cr、Cho/Cr比值差异有统计学意义(P<0.01);(4)脑胶质瘤的NAA/Cho、NAA/Cr比值与病理级别呈负相关,r分别为-0.782和-0.712;Cho/Cr比值与病理级别呈正相关,r=0.806.结论 ADC值和H1-MRS与胶质瘤的病理分级有明显相关性,可作为胶质瘤术前评价的依据.
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| 关 键 词： | 磁共振成像 扩散 氢质子磁共振波谱 胶质瘤 |
Study of relationship between apparent diffusion coefficient,H~1-MRS and histologic grading of brain gliomas |
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| Cui Jianhe,Bo Genji,Guo Lili.Study of relationship between apparent diffusion coefficient,H~1-MRS and histologic grading of brain gliomas[J].Chongqing Medical Journal,2011,40(14). |
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| Authors: | Cui Jianhe Bo Genji Guo Lili |
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| Abstract: | Objective To investigate the value of apparent diffusion coefficient(ADC)of diffusion-weighted imaging(DWI)and H1 MR spectroscopy(H1MRS)for brain gliomas.Methods 43 cases of histologically verified brain gliomas were studied conventional and enhenced MR imaging,DWI as well as H1-MRS.ADC values,relative ADC(rADC)of different portions of gliomas and contralateral normal brain white matter,NAA,Cho,Cr and Lac as well as ratios of NAA/Cho,NAA/Cr,Cho/Cr of gliomas and contralateral normal brain tissue were measur... |
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| Keywords: | magnetic resonance imaging diffusion H1-magnetic resonance spectroscopy glioma |
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