PAI-1蛋白在子宫内膜异位症组织的表达及意义

目的：探讨PAI-1蛋白在异位内膜、在位内膜厦对照组内膜的表达及意义。方法：应用免疫组化方法检测PAI-1蛋白在40例内异症组异位内膜及在位内膜，30例对照组子宫内膜的表达。结果：①PAI-1蛋白表达于异位内膜、在位内膜、对照组内膜的腺上皮细胞及间质细胞胞浆；②PAI-1蛋白在异位内膜厦对照组内膜间质细胞表达均高于腺上皮细胞（P〈0．05），而于在位内膜腺上皮细胞与间质细胞表达比较无统计学意义（P〉0．05）；③PAI-1蛋白在间质细胞表达异位内膜高于在位内膜及对照组内膜（P〈0．05），而在腺上皮细胞表达异住内膜、在位内膜、对照组内膜三者之间比较无统计学意义（P〉0．05）；④PAI-1蛋白在血管内皮细胞呈阳性表达。结论：PAI-1蛋白在异位内膜间质细胞高表达可能促使其转移、黏附、侵袭、生长，导致子宫内膜异住症的发生发展。

Expression and significance of plasminogen activator inhibitor-1 protein in endometriosis

Objective To investigate the expression of plasminogen activator inhibitor(PAI-1) in control endometrium,ectopic and eutopic endometrium with endometriosis. Methods Immunohistochemistry method was used to detect the expression of PAI-1 protein in 40 cases of ectopic endometrium,40 cases of eutopic endometrium and 30 cases of endometrium without endometriosis.Results PAI-1 protein was expressed in stromal and epithelial cells from control endometrium,ectopic and eutopic endometrium with endometriosis.PAI-1 protein tended to be higher from stromal cells in ectopic endometrium and control endometrium than from epithelial cells(P<(0.05)),but there was no statistical difference between stromal cells and epithelial cells in eutopic endometrium(P>0.05).Furthermore,the expression of PAI-1 was increased in endometriotic stromal cells compared with endometrial stromal cells(P<0.05),but there was nostatistical difference in epithelial cells among control endometrium,ectopic and eutopic endometrium(P>0.05).Conclusion The abnormal expression of PAI-1 protein might play an important role in the pathogenesis of endometriosis.