| 胆囊癌组织p53和PCNA表达及其相关性研究 |
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| 引用本文： | 谢小志,高宝辉,张海燕,赵志光.胆囊癌组织p53和PCNA表达及其相关性研究[J].诊断病理学杂志,2001,8(2):96-97,I029. |
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| 作者姓名： | 谢小志 高宝辉 张海燕 赵志光 |
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| 作者单位： | 温州医学院附属二院病理科浙江温州 325027 |
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| 摘 要： | 目的探讨胆囊癌组织学分级、淋巴结转移与p53、PCNA表达的关系,为临床判断恶性程度及预后提供参数.方法应用SP免疫组化方法,检测51例胆囊癌组织中n53、PCNA的表达水平.结果p53、PCNA在胆囊癌组织中表达的总阳性率分别为39.2%、56.9%,与胆囊癌的病理分级、转移密切相关(P＜0.01).p53表达与PCNA表达呈明显正相关.结论p53、PCNA是胆囊癌较特异的肿瘤标记物,其表达与胆囊癌淋巴结转移、病理分级有关.
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| 关 键 词： | p53 PCNA胆囊癌 免疫组织化学 |
| 文章编号： | 1007-8096(2001)02-0096-02 |
Expression of p53 and PCNA in gallbladder carcinoma and their relationship |
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| Xiaozhi Xie,Baohui Gao,Haiyan Zhang,et al..Expression of p53 and PCNA in gallbladder carcinoma and their relationship[J].Chinese Journal of Diagnostic Pathology,2001,8(2):96-97,I029. |
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| Authors: | Xiaozhi Xie Baohui Gao Haiyan Zhang |
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| Institution: | Xiaozhi Xie,Baohui Gao,Haiyan Zhang,et al. Department of Pathology,Second Affiliated Hospital,Wenzhou Medical College,Wenzhou 325027 |
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| Abstract: | Objective To study the correlation of the expression of p53 and PCNA with pathological grading and metastasis. Method SP immunohistochemical technique was used to investigate the expression of p53 and PCNA in 51 cases of gallbladder carcinoma. Results The positive rate of p53 and PCNA was 39.2% and 56.9% respectively, which was positively correlated with the pathological grading and metastasis of the tumor ( P <0.01). There was a close relationship between the expression of p53 and PCNA in the tumor. Conclusion p53 and PCNA may be important biological markers to evaluate the malignancy and prognosis of gallbladder carcinoma. |
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| Keywords: | Gallbladder carcinoma P53 PCNA Immunohistochemistry |
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